Assume you have a starship that can fly FTL through real space by accelerating. Yeah that should kill you from G force alone, but your ship creates gravity own it's own, so you have a counter gravitational force so that you don't die.
Now onto navigation. Everybody knows even galaxies move, everything in the universe moves. Seems to me that a good way to travel would be to just follow orbits, even at FTL. The reason being because if you fly in straight lines, your chances of flying off course increase. Everything in the galaxy seems to follow orbits of one kind or another, so I think following predictable orbits would likely be the ONLY way you will navigate effectively (at great distances).
What's the point of flying straight when the planet you wanna get to will have moved by the time you get there?
So all travel would follow curved routes, until you reach your destination. It may take a bit longer than flying straight, or it may even get you there faster.
At any rate it would be predictable, since your computers should be advanced enough to calculate orbital paths just from observation, because I'm including long range FTL sensors.