Specifically, the refutation that one cannot "know" anything for sure. This comes courtesy of Descarte.
One's qualia or "subjective conscious experience" is sufficient for justifying the existence of something beyond the shadow of a doubt. For example, I am 100% positive that my computer exists, simply because I am experiencing it. No matter if this computer exists as a physical object, a sensory illusion, or a false memory, no matter what this computer ultimately exists as, it still exists nonetheless (even if only as a quale).
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