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Thread: Initial findings on anti-aging.

  1. #1 Initial findings on anti-aging. 
    Your Mama! GiantEvil's Avatar
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    Australian and US scientists reverse ageing in mice, humans could be next - ABC News (Australian Broadcasting Corporation)
    Is this actually something to be a little excited about?
    If so, the implications are massive.


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    Do you mean that someday The Curious Case of Benjamin Button will be exceedingly (more) boring?


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    I think the most exciting part of the research is that you can target a specific anatomical weakness. Putting upper body strength back into men over 70 or leg strength for anyone and everyone - or after illness at any age - means that we can limit or ameliorate the disability and the long-term consequences of illness or injury regardless of length of life. Quicker recovery from adverse events throughout life and longer period of a good quality of life when aged means that we can live "more life" within the same span of life - even if there is no increase in total years alive.

    More lively life for longer.

    (And I'm secretly hoping there might be a flow on for people with conditions like my own. Even if it has no direct effect on the decreasing/ dying nerve pathways to the feet and legs, ensuring maximum strength of whatever functioning muscle is there would mean better function for longer. I'm not concerned about length of life - my family routinely live to 85 or 90 or longer - but how good those last 10 or 15 years are is a matter for concern to me.)
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    I don't know what say but the post is very intriguing.
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    Quote Originally Posted by GiantEvil View Post
    Australian and US scientists reverse aging in mice, humans could be next - ABC News (Australian Broadcasting Corporation)
    Is this actually something to be a little excited about?
    If so, the implications are massive.
    A longer better quality life would be very nice. But in a world that has more people than it maybe should have, if we live longer lives, then we need fewer children being born. Which is fine with me, but I know a few people that would be violently against restricting how many children they can have.
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    Google "education and birth rate". Education is the primary correlate to lower birth rates.
    Check out this too; http://en.wikipedia.org/wiki/Mooc
    Anybody with a device and internet connection can get a free education.
    My population control plan? Computers/devices/internet for everyone.
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    I'm kinda' skeptical about the original claim.

    Don't you think something like that would be in the news more?
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    Quote Originally Posted by GiantEvil View Post
    Google "education and birth rate". Education is the primary correlate to lower birth rates.
    Check out this too; Massive open online course - Wikipedia, the free encyclopedia
    Anybody with a device and internet connection can get a free education.
    My population control plan? Computers/devices/internet for everyone.
    That would be only partially effective. Just because education is available doesn't mean most people would make use of it. We need to develop a reversible vaccine against pregnancy to stop all unintended births until a couple request the antidote they will not have children.
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    We need to develop a reversible vaccine against pregnancy to stop all unintended births until a couple request the antidote they will not have children.
    Don't see why. We already have contraceptive implants for women that last for 3 years. Some IUDs are effective for 5 years. Both of these methods can be improved.

    The biggest problem for these methods is that they don't protect against transmission of STIs, but nor would a fertility vaccine. Perhaps vaccines against STIs would be a better target. The HPV vaccine is a good start in this area even though it's really directed against later consequences - like cancer. There's no good reason why we shouldn't be looking at vaccines for things like chlamydia or gonorrhea or syphilis (I don't even know if that's possible, but it's be great if it could be done.)
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  11. #10  
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    Quote Originally Posted by adelady View Post
    We need to develop a reversible vaccine against pregnancy to stop all unintended births until a couple request the antidote they will not have children.
    Don't see why. We already have contraceptive implants for women that last for 3 years. Some IUDs are effective for 5 years. Both of these methods can be improved.

    The biggest problem for these methods is that they don't protect against transmission of STIs, but nor would a fertility vaccine. Perhaps vaccines against STIs would be a better target. The HPV vaccine is a good start in this area even though it's really directed against later consequences - like cancer. There's no good reason why we shouldn't be looking at vaccines for things like chlamydia or gonorrhea or syphilis (I don't even know if that's possible, but it's be great if it could be done.)
    Any vaccine against disease is a very good thing, but I was thinking it would be mandatory for all children before they are able to get pregnant and reversed when they are married and want children of their own. If all children were wanted and born into a stable relationship, that would sure be better than the way we do it now. So all children would be wanted and there would be a lot less births, so we all could enjoy a longer healthier life in a world with a lot less crime.
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    Quote Originally Posted by Beer w/Straw
    I'm kinda' skeptical about the original claim.
    Article links to an abstract in a peer reviewed journal. There are several well known institute names associated as well; Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
    Quote Originally Posted by Bad Robot
    That would be only partially effective. Just because education is available doesn't mean most people would make use of it.
    Umm... What part of "education is the primary correlate of low birth rate" do you not understand? Also I suspect that your premise that humans will generally fail to exploit a resource is fundamentally not accurate.
    Quote Originally Posted by Bad Robot
    We need to develop a reversible vaccine against pregnancy to stop all unintended births until a couple request the antidote they will not have children.
    Full Stop! Survivors unable to reproduce after catastrophic event, humans go extinct. Bad idea man. I go bullets before I let that happen.
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    [QUOTE=GiantEvil;507252]
    Quote Originally Posted by Bad Robot
    That would be only partially effective. Just because education is available doesn't mean most people would make use of it.
    Umm... What part of "education is the primary correlate of low birth rate" do you not understand? Also I suspect that your premise that humans will generally fail to exploit a resource is fundamentally not accurate.
    If we have longer healthier lives even the current (so called low birth rate) of the industrialized better educated countries will still be to high and still doesn't deal with all the unwanted children born each year and the high crime rates do to high rates of poverty and drug addiction and gangs that dominate the cities.

    Quote Originally Posted by Bad Robot
    We need to develop a reversible vaccine against pregnancy to stop all unintended births until a couple request the antidote they will not have children.
    Full Stop! Survivors unable to reproduce after catastrophic event, humans go extinct. Bad idea man. I go bullets before I let that happen.
    I'm talking about a fully reversible procedure to the anti-pregnancy vaccine. Not sure what kind of catastrophic event you might be talking about that would prevent that from happening.
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    Quote Originally Posted by Bad Robot
    If we have longer healthier lives even the current (so called low birth rate) of the industrialized better educated countries will still be to high and still doesn't deal with all the unwanted children born each year and the high crime rates do to high rates of poverty and drug addiction and gangs that dominate the cities.
    I'm afraid I need some references and numbers about your first sentence. Unwanted children is not a result of a low birth rate. All the other societal ills you have listed have an inverse correlation to education as well.
    Quote Originally Posted by Bad Robot
    I'm talking about a fully reversible procedure to the anti-pregnancy vaccine. Not sure what kind of catastrophic event you might be talking about that would prevent that from happening.
    Reversible by what specialists after a catastrophic event? Oh, you know, virus, giant rock from space, supervolcano, nuclear exchange, AI rebellion, etc...
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    Just came across this excellent overview of the mice mitochondria paper and associated news reports.

    The most disappointing thing is that the reported effects on muscle tissue didn't have any effect on muscle strength. Phoooey. Oh well. It's worth a read anyway.

    One thing we have certainly learned over the last couple of centuries is that biochemistry and physiology are complex webs of interactions. Our bodies are Rube Goldberg machines, evolved over millions of years to work well enough. Our biology is like code that has been patched, upgraded, and expanded millions of times – it’s a mess.

    Another meta-lesson from medical science is that pulling on one thread in the complex biological web rarely has simple or predictable outcomes. If one small change has a clear positive outcome without any downsides, we probably would have evolved that solution long ago. Rather, biological interventions tend to have complex outcomes with many side effects.

    What the researchers have found here is one tiny slice of the regulation of mitochondrial function – lower levels of NAD+ with ageing contribute to the decline in mitochondrial function, and artificially raising NAD+ levels restores certain measured aspects of mitochondrial function.

    Here is what we do not know – what are the net effects on cell function of prolonged increase in NAD+, what are the net health effects on the organism, are such effects sustained, what are the negative effects?


    Reverse Ageing Hype Science-Based Medicine
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    Oh yeah, media hype. I'm not terribly, or at all, surprised. But hey, it is some news. Better than no news.
    What really gets me, is people who come out the gate with "Extending human life would lead to such great tragedy." Obviously there will be issues to be addressed, but hey, we can put probes on other planets. We can handle the future. If someone is against living a longer healthier life, than I don't think we should force them. But they really need to stay out'a my way if they don't want to get hurt.
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    Quote Originally Posted by Melissa Willow View Post
    I found a company selling a supplement containing NAD called "Zao Reset" and am thinking of trying it. Has anyone else tried this product yet?
    You get an impressive list of ingredients for your $170. I would say if you do get it, try only taking half or one third the dose they are recommending, that way you get those ingredients daily for longer. Just thinking for that kind of money they will hope you use it up much faster.

    Zao NeuroRenew Supplement Facts Serving Size: 6 Capsules and 1 Tablet Serving Per Container: 60 Zao Essential Serving Size: 1 Capsule Each capsule contains: Vitamin A 3000IU, Vitamin C 40mg, Vitamin D 80IU, Vitamin E 30IU, Vitamin K 20mcg, Vitamin B1 10mg, Vitamin B2 10mg, Vitamin B6 12mg, Niacin 10mg, Vitamin B12 80mcg, Folic Acid 200mcg, d-Biotin 180mcg, Pantothenic Acid 5mg, Calcium 25mg, Iron Citrate 3mg, Iodine 40mcg, Magnesium 55mg, Zinc 5mg, Selenium 20mcg, Copper 0.3mg, Manganese 0.5mg, Chromium 30mcg, Molybdenum 19mcg, Potassium 24mg, Silica 3mg, Choline 20mg, Quercetin 5mg, Alpha Lipoic Acid 15mg, Lutein Esters 10% 1mg, Lycopene 5% 1mg, Grape Seed Extract 10mg, Pine Bark Extract 10mg, Ginkgo Bilboa Powder 15mg, Bilberry Fruit Extract 8mg, Green Tea Leaf Extract 3mg, Taurine 10mg, Gama Oryzanol 10mg, Para-Amino Benzoic Acid 20mg, Inositol 12mg, Boron 5mcg. Other ingredients: Gelatin, Magnesium Stearate, Silica. Vitamin C Serving Size: 1 Tablet Each Tablet Contains: Vitamin C (Ascorbic Acid) 1000mg, Citrus bioflavonoids 50mg. Other Ingredients: Steric Acid, Microcrystalline Cellulose, Magenseium Stearate, Silica. Zao B Complete Serving Size: 1 Capsule Each Capsule Contains: Vitamin B1 20mg, Vitamin B6 22mg, Vitamin B2 15mg, Niacin 30mg, Vitamin B12 100mcg, Calcium Pantothenate 100mg, Pantethine 5mg, Folate 200mcg, Magnesium 30mg, Zinc 3mg, D-Biotin 300mg, Taurine 20mg, Choline Bitartate 60mg, Para-Amino Benzoic Acid 40mg, Inositol 30mg, Alpha Lipoic Acid 20mg, Pine Bark Extract 10mg, Ginkgo Bilboa 10mg, Grape Seed Extract 10mg, Lycopene 1mg, Bilberry Fruit Extract 10mg. Other Ingredients: Gelatin, may also contain, Microcrystalline Cellulose, Magnesium Stearate, Silica. Zao Amino Basic Serving Size: 3 Capsules Each Serving Size Contains: L-Lysine, L-Trytophan, L-Arginie Base, L-Isoleucine, L-Alanine, L-Threonine, L-Histidine, L-Methionine, L-Cystine, L-Glutamine, L-Tyrosine, L-Aspartic Acid, L-Valine, L-Glutamic Acid, L-Phenylalanine, Glycine, L-Serine, N-Acetyl-L-Cysteine, Gelatin, Microcrystalline Cellulose, Magnesium Stearate. Zao Cell Recharge Serving Size: 1 Capsule Each Capsule Contains: L-Glutathione Reduced 250mg. Other Ingredients: Gelatin, may also contain, Microcrystalline Cellulose, Silica, Vegetable Steric Acid. Zao NeuroReset Supplement Facts Serving Size: 1 Tablet Each Enteric Tablet Contains: Niacin 10mg, Proprietary Blend 70mg: B-Nicotinamide aderine dinucleotide trihydrate, L-Tryptophan. Other Ingredients: Calcium carbonate, microcrystalline cellulose, ethyl cellulose, stearic acid, magnesium stearate, silica, sodium alginate, oleic acid, croscamellose sodium, medium chain triglycerides. Does not contain: Starch, corn, milk, wheat, yeast, sugar, eggs, salt, artificial colors, flavors, preservatives or animal products.

    Price: $169.95
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