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Thread: Comprehensive Cancer Biomarker Database Launched

  1. #1 Comprehensive Cancer Biomarker Database Launched 
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    A unique oncology biomarker database with cancer companion diagnostic pathway maps

    With the growing trend of personalized healthcare concept and advancement in biomarker research, there is a need for a comprehensive cancer biomarker database that can help in finding new diagnostic, prognostic and companion diagnostic biomarkers. Future success in developing innovative personalized cancer drugs lies in adopting new differential diagnostic procedures along with companion biomarker assays to identify the most appropriate cancer patient, tumor type and disease state.

    Sciclips has launched a comprehensive diagnostic and prognostic cancer biomarker database with cancer companion diagnostics biomarker pathway maps. This database contains more than 8500 discovery phase or preclinical or clinical cancer biomarkers that were identified or validated using patient derived samples. This database covers a wide variety of biomarkers such as blood cancer biomarkers (peripheral blood, plasma, serum etc), tumor biomarkers, urinary cancer biomarkers, fecal cancer biomarkers, saliva cancer biomarkers, breath cancer biomarkers etc.

    Our cancer biomarker database contains biomarkers for more than 100 types of cancer. For each cancer type, the biomarkers are classified into 1) diagnostic biomarkers: for the diagnostics application, 2) disease predictive/risk assessment biomarkers: for predicting the risk or genetic susceptibility in developing cancer, 3) drug efficacy/response biomarkers: biomarkers for studying the efficacy of anti-cancer drug treatments, including predictive biomarkers and 4) prognostic biomarkers: for determining the clinical outcome in cancer patients. The types of cancer biomarkers include protein biomarkers, miRNA biomarkers, SNP biomarkers, Gene expression biomarkers, epigenetic biomarkers and metabolomic biomarkers. Patient/sample details, experimental results/observations, biological and molecular functional analysis, biological process analysis, protein-protein interaction networks of each biomarker are listed in this database. This database will be a useful tool for the discovery of new cancer biomarkers as well as clinical validation of biomarkers.

    The cancer companion diagnostics biomarker pathway database is an innovative database of protein-protein interactions networks of cancer drug efficacy/response/predictive biomarkers. This pathway maps can be used for identifying new anti-cancer drug predictive and response biomarkers, for the discovery of new drug targets with improved efficacy or targeted therapy to overcome side effects, patient stratification, developing personalized strategies for monitoring cancer progression, treatment, diagnosis and prognosis.
    Please follow this link to view the database (preview is available): Diagnostic and Prognostic cancer biomarker database


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  3. #2  
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    Quote Originally Posted by Tonny View Post
    A unique oncology biomarker database with cancer companion diagnostic pathway maps

    With the growing trend of personalized healthcare concept and advancement in biomarker research, there is a need for a comprehensive cancer biomarker database that can help in finding new diagnostic, prognostic and companion diagnostic biomarkers. Future success in developing innovative personalized cancer drugs lies in adopting new differential diagnostic procedures along with companion biomarker assays to identify the most appropriate cancer patient, tumor type and disease state.

    Sciclips has launched a comprehensive diagnostic and prognostic cancer biomarker database with cancer companion diagnostics biomarker pathway maps. This database contains more than 8500 discovery phase or preclinical or clinical cancer biomarkers that were identified or validated using patient derived samples. This database covers a wide variety of biomarkers such as blood cancer biomarkers (peripheral blood, plasma, serum etc), tumor biomarkers, urinary cancer biomarkers, fecal cancer biomarkers, saliva cancer biomarkers, breath cancer biomarkers etc.

    Our cancer biomarker database contains biomarkers for more than 100 types of cancer. For each cancer type, the biomarkers are classified into 1) diagnostic biomarkers: for the diagnostics application, 2) disease predictive/risk assessment biomarkers: for predicting the risk or genetic susceptibility in developing cancer, 3) drug efficacy/response biomarkers: biomarkers for studying the efficacy of anti-cancer drug treatments, including predictive biomarkers and 4) prognostic biomarkers: for determining the clinical outcome in cancer patients. The types of cancer biomarkers include protein biomarkers, miRNA biomarkers, SNP biomarkers, Gene expression biomarkers, epigenetic biomarkers and metabolomic biomarkers. Patient/sample details, experimental results/observations, biological and molecular functional analysis, biological process analysis, protein-protein interaction networks of each biomarker are listed in this database. This database will be a useful tool for the discovery of new cancer biomarkers as well as clinical validation of biomarkers.

    The cancer companion diagnostics biomarker pathway database is an innovative database of protein-protein interactions networks of cancer drug efficacy/response/predictive biomarkers. This pathway maps can be used for identifying new anti-cancer drug predictive and response biomarkers, for the discovery of new drug targets with improved efficacy or targeted therapy to overcome side effects, patient stratification, developing personalized strategies for monitoring cancer progression, treatment, diagnosis and prognosis.
    Please follow this link to view the database (preview is available): Diagnostic and Prognostic cancer biomarker database
    Tonny, with respect, you are trying to close the door after the horse has bolted.
    The true adversary in cancer is prevention, not an innovative database you suggest, and all your
    prognostications you present in your post about drugs being a solution, is counter-productive.
    I will, leave you with this to consider, Tonny, It's not what you eat, but what you don't eat
    that kills you.
    nokton.


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  4. #3  
    Time Lord Paleoichneum's Avatar
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    What exactly are you trying to say nokton?
    If more of us valued food and cheer and song above hoarded gold, it would be a merrier world. -Thorin Oakenshield

    The needs of the many outweigh the need of the few - Spock of Vulcan & Sentinel Prime of Cybertron ---proof that "the needs" are in the eye of the beholder.
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    Quote Originally Posted by Paleoichneum View Post
    What exactly are you trying to say nokton?
    Paleo, my friend, what I am saying is this. Prevention is better than cure.
    But in so many cases, trying to find the cure takes precedence over
    the cause.
    Recently published studies indicate that people that include fruit and veg in
    their diet on a regular day to day basis have a 50% less chance of getting cancer
    than those who don't. Pity more attention was not paid to these findings Paleo,
    But as always, my friend, money talks, drugs generate profit, sound advice does not.
    Hope this answers your question,
    nokton.
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  6. #5  
    Brassica oleracea Strange's Avatar
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    Quote Originally Posted by nokton View Post
    Recently published studies indicate that people that include fruit and veg in
    their diet on a regular day to day basis have a 50% less chance of getting cancer
    than those who don't.
    That still leaves half the people who will need medical help. (Assuming you can get 100% people to improve their lifestyle).
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    Take your point Stange, and agree in principal, though where you get 'half' from, I would question.
    One can take a horse to water, but you can't make it drink comes to mind.
    Promoting ones good health involves a certain lifestyle that many eschew.
    But that is freedom of choice, and I would totally defend freedom of choice.
    However, Strange, real choice is dependent on evaluation by the individual
    of the relevant information available.
    And that information is many times conflicting.
    nokton
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  8. #7  
    Brassica oleracea Strange's Avatar
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    Quote Originally Posted by nokton View Post
    Take your point Stange, and agree in principal, though where you get 'half' from...
    Well, if a better lifestyle reduces the chances of cancer by 50%, presumably the other 50% are going to get it anyway.
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    With due respect Strange, expected a modicum more of understanding in your response.
    You misinterpreted my post entirely. My point was, and is, that those who eat veg and
    fruit every day are 50% less likely to develop cancer. That does no way equate to 50%
    of the population, nor did I suggest that.
    I am somewhat perplexed by your response, and, again with respect, your attitude
    to something that is a matter of much concern now, does not interest you.
    nokton
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  10. #9  
    Brassica oleracea Strange's Avatar
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    Quote Originally Posted by nokton View Post
    With due respect Strange, expected a modicum more of understanding in your response.
    You misinterpreted my post entirely. My point was, and is, that those who eat veg and
    fruit every day are 50% less likely to develop cancer. That does no way equate to 50%
    of the population, nor did I suggest that.
    I am somewhat perplexed by your response, and, again with respect, your attitude
    to something that is a matter of much concern now, does not interest you.
    nokton
    I didn't mean half the population.

    OK. Let's say some (hopefully small) proportion of the population is going to get cancer, a total of N people. Now by improving diet and lifestyle half of those (N/2) can avoid the disease. That is obviously a great improvement and we should do all we can to get there.

    That still leaves half (N/2) who will get cancer anyway and will need medical help. But you seemed to be suggesting that it was a waste of time/money developing this database, drugs, etc.

    We need both prevention and cure.
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  11. #10  
    Time Lord Paleoichneum's Avatar
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    Nokton- What is your source for a 50% decrease in cancer rates? All cancers?

    The opening post of this thread was about a database of cancer biomarkers, which would be used by those who have cancer. This makes stranges post very much in line with the topic.
    If more of us valued food and cheer and song above hoarded gold, it would be a merrier world. -Thorin Oakenshield

    The needs of the many outweigh the need of the few - Spock of Vulcan & Sentinel Prime of Cybertron ---proof that "the needs" are in the eye of the beholder.
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  12. #11  
    Brassica oleracea Strange's Avatar
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    This recent report suggest that 40% of cancers are lifestyle related. Obviously, smoking is the most important factor.
    BBC News - Over 40% of cancers due to lifestyle, says review
    However,
    In men, 6.1% (9,600) of cancer cases were linked to a lack of fruit and vegetables
    And for women, the figure was even lower.
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    The applications of biomarkers are beyond the diagnosis of a patient for the detection of the presence of a cancer. Biomarkers can be used for determining whether a patient will respond to a particular therapy (e.g. chemotherapy) or for monitoring the progression of disease during a particular treatment regimen. This would allow physicians to make a decision on treatment strategies for a patient (individualized treatment/personalized treatment). This approach may ultimately help in improving the recovery/survival rate in cancer patients.

    Biomarkers can also be used for predicting likelihood or the risk in developing a cancer, especially by identifying the genetic predisposition to develop a cancer. If an individual has a genetic background that triggers cancer development at some point in his/her lifetime, irrespective of the fact that a person eats fruits or vegetables, biomarkers will help to identify the risk and help in developing prevention strategies.

    Prevention will be the most effective approach if can pinpoint the cause, which we did not understand yet with respect to cancers. Again, cancer causing factors are not definitive or can’t be generalized since individuals respond differently to any such cancer causing factors.

    Tonny
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    Quote Originally Posted by Strange View Post
    Quote Originally Posted by nokton View Post
    With due respect Strange, expected a modicum more of understanding in your response.
    You misinterpreted my post entirely. My point was, and is, that those who eat veg and
    fruit every day are 50% less likely to develop cancer. That does no way equate to 50%
    of the population, nor did I suggest that.
    I am somewhat perplexed by your response, and, again with respect, your attitude
    to something that is a matter of much concern now, does not interest you.
    nokton
    I didn't mean half the population.

    OK. Let's say some (hopefully small) proportion of the population is going to get cancer, a total of N people. Now by improving diet and lifestyle half of those (N/2) can avoid the disease. That is obviously a great improvement and we should do all we can to get there.

    That still leaves half (N/2) who will get cancer anyway and will need medical help. But you seemed to be suggesting that it was a waste of time/money developing this database, drugs, etc.

    We need both prevention and cure.
    Thankyou Strange, totally agree with you on your statement of prevention and cure,
    but, as the bard would have said, theres the rub.
    As for prevention, how does one convince another of the value of foods
    that promote good health when they enjoy their pizzas and take aways.
    Fresh fruit and veg contain anti-oxidents that are known to reduce cancer risk,
    as well as heart disease. But getting the message across falls on many deaf ears.
    So, and forgive me for this, the drug companies profit from the deaf ears
    when things go wrong.
    The solution Strange? I do not know my friend. One can persuade and educate,
    but convince, is another matter.
    Thankyou your response.
    nokton.
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  15. #14  
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    @Nokton.........

    It is very true that good food is essential for good health but that can't be extended to conclude about drug research. You may need medication anytime even if you lead a healthy lifestyle. So the benefit of drug research is starting from there.
    I think the genetic cause of cancer can,t be recoverable by any means of foods or vegitables. However I have no idea about research/data on the epigenetic changes and good life styles. You also have to careful about the values from these studies because most of the cases it is very short term studies with less number of patients. I hope it will be helpful.

    Thanks
    Arindam
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    I had read somewhere that science was able to reverse the mechanism that make cancer cells immortal so they will die. Is this true?
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    Biomarkers are critical so we need to lobby for a more efficient biomarker establishment system, ASAP, given the mother lode of data pouring in from the TCGA et al. See this article, linking to the Science article:
    Taming the Tumor Genetics Revolution
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