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Thread: Question about Smoking Carcinagons

  1. #1 Question about Smoking Carcinagons 
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    i read about it from wikipedia

    http://en.wikipedia.org/wiki/Benzopyrene

    Benzo[a]pyrene is found in coal tar, in automobile exhaust fumes (especially from diesel engines), tobacco smoke, and in charbroiled food. Recent studies have revealed that levels of benzo[a]pyrene in burnt toast are significantly higher than once thought, although it is unproven whether burnt toast is itself carcinogenic.
    it says it occurs in coal tar and burnt toast, i understand it being a hydrocrabon it would be found in coal tar but how would it occur in burnt toast? And i also read somewhere that Benzopyrene is found in marijuana, how does it get there? is it added artifically?Are there more concentrations of it then tobacco?

    This molecule intercalates in DNA, covalently bonding to the nucleophilic guanine nucleobases at the N2 position. X-ray crystallographic and nuclear magnetic resonance structure studies show that this binding distorts the DNA,[5] inducing mutations by perturbing the double-helical DNA structure.
    so does that mean the bonding created between the Benzopyrene to the DNA causes the mutations like cancer? I dont understand those huge words if can anyone translate to idiot plz (i would like to know more about this please, if anyone can link me articles or reply)

    Thanks 8)


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  3. #2  
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    well that's what it sounds like... isnt all cancer just mutations in dna caused by an outside source?

    i dont know myself but i run across any articles that could be helpful for you ill post them up.


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  4. #3  
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    It occurs in toast as there is incomplete combustion as the article says.
    If its in marijuana Im guessing you/whoever said it means its produced as it's burnt/smoked, it wouldnt be added artificially, I doubt marijuana manufacturing could be so organised!

    A basic translation for your quote would be...
    "the molecule associates itself with the DNA double helix and binds to an enzymes covalently (guanine nucleobases) an the enzymes reaaily bind to DNA. Xray crystallography and nuclear magnetic resonance are just imaging techniques to observe whats happening. The binding of the molecule distorts the double helix of the DNA and this can cause mutations."
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  5. #4  
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    cool thanks guys
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  6. #5  
    墨子 DaBOB's Avatar
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    Where's the doc when you need him? Although Robbies explanation sounds pretty good. Would that imply that removing this chemical would remove the dangerous effects of the drug? I doubt it.
    Do not try and bend the spoon. That's impossible. Instead... only realize the truth. There is no spoon. Then you'll see that it is not the spoon that bends, it is only yourself. -Spoon Boy
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  7. #6  
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    when sells multiply they make nearly exact copies of themselves. These small changes are natural and can be seen as aging. cancer is when there is abnormal and drastic changes were the new cell will multiply but not die. this is a cancerous cell this first mutation rapidly multiplies until there is a 2nd mutation and so forth until the cell has changed and multiplied so much it is severly different from the original tissue and now draws far more of the bodies resources than before. It gets to a stage were it emits a certain chemical (cant remember the name) which causes the body to grow blood vessels around it. If this is succesful the cancerous cells can now travel around the body and create new colonies if they do that it is now malignant so it can spread. Any chemical or energy source such as gamma rays that cause this are said to be carcinogenic. The simplicity which is involved in ruining a cells multiplication is staggeringly easy and in truth their is probably a larger number of carcinogenics in the world than we would care to think about sometimes think certain political financial arrangemets get in the way of the truth
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  8. #7  
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    ok, then ifyou wan to talk about cancer.For cancer, 6 successive mutations are needed for malignancy which at each stage give the cell a growth advantage. These mutations need to make 6 physiological changes to the cell; namely

    Must be self sufficient in growth signals
    unresponsive/insensitive to growth inhibition signals
    must not engage in apoptosis
    must have limitless replication potential
    must be able o sustin angiogenesis
    and metastasis.

    the chances of such mutations occuring is PHENOMONALLY low in any individual cell, even in presence of carcinogens due to the many mechanisms in plce within the cell to prevent errors in DNA replication, protein synthesis etc. However due to the shear number of cells in our bodies, it becomes more likely that this can occur, and carcinogens can contribute to this.

    There are actually many angiogenic factors but I think your referring to vascular endothelial growth factor or epidermal growth factor.
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  9. #8  
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    Im not sure what ur point is but the way i see it is that a carcinogenic is anything that promotes an abnormal mutation in a cell so facilitating the production of cancer whether or not the cell makes it to the level of being malignant or even survives after it mutates is irrelevant. I would think that since the only thing needed for such problems are the denaturing or change in composition of single molecules of dna which is as simpley done as reacting it with other molecules or breaking it apart through the exposure to any radiatiion i would think there would be a large number of potentially carcinogenic substances that was all i was saying
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