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Thread: Pithovirus

  1. #1 Pithovirus 
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    Hi all. I'm new here, and joined just so I could ask a question thats sprung to my mind.
    So today I was reading about the re-discovery of Pithovirus Sibericum, which had been in hibernation for the last 30,000 years. I note that it kills amoeba, but is not destructive to humans or animals.
    I also happened to earlier be reading about Naegleria Fowleri...a nearly always fatal amoeba which attacks the human brain.

    Could anyone with the correct knowledge answer the question...Is there a possibility of this Pithovirus being a possible treatment to the Naegleria Fowleri?

    Thanks,

    John


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    I also hope this is in the right forum - it seemed the best fit


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    Universal Mind John Galt's Avatar
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    Definitely the right forum and an interesting question. I'm not qualified to even attempt an answer, but here are a couple of links for other members.

    Wikipedia - Pithovirus
    Nature News

    Wikipedia - Naegleria Fowleri
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  5. #4  
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    Thanks John
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  6. #5  
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    Quote Originally Posted by Johnmacmillan View Post
    Could anyone with the correct knowledge answer the question...Is there a possibility of this Pithovirus being a possible treatment to the Naegleria Fowleri?

    It would be fantastic if the administration of P. sibericum is a viable treatment for a N. fowleri infection,
    yet, as far as I can tell, your question is unanswerable because more investigations of these newly discovered viruses are required.
    "The only safe rule is to dispute only with those of your acquaintance of whom you know that they possess sufficient intelligence and self-respect not to advance absurdities; to appeal to reason and not to authority, and to listen to reason and yield to it; and, finally, to be willing to accept reason even from an opponent, and to be just enough to bear being proved to be in the wrong."

    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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  7. #6  
    Forum Masters Degree mat5592's Avatar
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    It could be possible, but viruses tend to be very specific to only a few species.
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  8. #7  
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    What if someone decided to genetically alter a P. sibericum to infect N. fowleri specifically?
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    Quote Originally Posted by viagratrix View Post
    What if someone decided to genetically alter a P. sibericum to infect N. fowleri specifically?
    Go for it. You might be able to use it as a home remedy but to market it you'd have a big problem proving it was safe.
    Look up the rules.
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  10. #9  
    Moderator Moderator Cogito Ergo Sum's Avatar
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    Quote Originally Posted by viagratrix View Post
    What if someone decided to genetically alter a P. sibericum to infect N. fowleri specifically?

    Then more questions arise, such as:
    What dose of P. sibericum (alt.) is sufficient to treat the infection?
    Is one dose enough or are more doses required?
    How is the dose administrated?
    How many altered viruses are in one dose?
    Are there any side-effects?

    etc.
    "The only safe rule is to dispute only with those of your acquaintance of whom you know that they possess sufficient intelligence and self-respect not to advance absurdities; to appeal to reason and not to authority, and to listen to reason and yield to it; and, finally, to be willing to accept reason even from an opponent, and to be just enough to bear being proved to be in the wrong."

    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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  11. #10  
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    clinical trials?
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  12. #11  
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    Quote Originally Posted by viagratrix View Post
    clinical trials?

    What do you mean?
    "The only safe rule is to dispute only with those of your acquaintance of whom you know that they possess sufficient intelligence and self-respect not to advance absurdities; to appeal to reason and not to authority, and to listen to reason and yield to it; and, finally, to be willing to accept reason even from an opponent, and to be just enough to bear being proved to be in the wrong."

    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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  13. #12  
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    I mean that there should be trials to find the answer to the questions you asked. First and foremost testing the virus with N. fowleri to see if it requires genetic modification. Then in vitro or ex vivo testing. After possible success comes human trials
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  14. #13  
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    clinical trials so to speak. Sorry if i make no sense i'm finnish
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  15. #14  
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    Pandora viruses could also be used in the same manner as we discussed
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  16. #15  
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    Quote Originally Posted by viagratrix View Post
    I mean that there should be trials to find the answer to the questions you asked. First and foremost testing the virus with N. fowleri to see if it requires genetic modification. Then in vitro or ex vivo testing. After possible success comes human trials clinical trials so to speak.
    Pandora viruses could also be used in the same manner as we discussed

    It is an hypothesis worth exploring, but it is not yet proposed.
    Bear in mind though, that we do not know what the effects are of P. sibericum (or other pandoraviruses) on N. fowleri (or human health).
    "The only safe rule is to dispute only with those of your acquaintance of whom you know that they possess sufficient intelligence and self-respect not to advance absurdities; to appeal to reason and not to authority, and to listen to reason and yield to it; and, finally, to be willing to accept reason even from an opponent, and to be just enough to bear being proved to be in the wrong."

    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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