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Thread: Drugs/substances that can increase/decrease pheomelanine/eumelanine production

  1. #1 Drugs/substances that can increase/decrease pheomelanine/eumelanine production 
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    Hi all!Firstly,I am a real geek and love science in all its forms.I argued with some friends(they are geeks as me,lol)that if,let's say an African person can increase he's pheomelanine production and reduce eumelanine permanently,he could become fair skinned and red/blonde haired,of course he would still retain the facial features of an African person,but skin and hair would be lighter.This would be true also for let's say an English person,who is rosy-milky skinned,blue eyes and red hair,if his eumelanine production would increase drastically he would gradually become darker,not necessarily African-like black but darker.This would be true?One of my friends told his wife about this,who is a really rich woman,she is of African ethnicity,and would pay thousands even millions of pounds just to become an auburn/red haired fair skinned person,She contacted me and made an offer:she will donate a huge sum of money for my foundation which helps children with leuchemia(I won't give any name,I'm not making ads here,all I can say is I am from London).She knows that once I worked in a laboratory which made several experiences with drugs on animals,like mice and rats,unfortunately I was never interested in this before,I worked in the field of bone/muscle manipulation(and no,I don't sell steroids and HGH),but a donation would be more than welcomed for my foundation.I tried to google it,but found nothing really helpful,can anyone help me out with tis one,or at least what kind of doctor should I consult(I left the field of medicine 10 years ago,so I don't really know what direction I should take).Any suggestion is welcome,even if it's dangerous(I will test it on mice first,however).Thanks in advance guys!I hope also that it's in the right section!


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  3. #2  
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    Any suggestion is welcome,even if it's dangerous(I will test it on mice first,however).
    I do not know what about melanin level suppression ( I afraid you would need to take such pills regularly ), but if somebody wants to change his/her skin colour permanently and for a life, then the cheapest and easiest solution - make tattoo on the surface of the whole skin that is present on your body. I guess you could select some colour shade of a tattoo paint that will make it look beauty and healthy. But this is cheap solution for a poor. I do not know what is available for a rich people, Michael Jackson already tried something like this. Why this woman want to change her skin colour, does she believes it will look more beautiful, or she want to change relation of white people to her race?


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    Quote Originally Posted by Stanley514 View Post
    Any suggestion is welcome,even if it's dangerous(I will test it on mice first,however).
    I do not know what about melanin level suppression ( I afraid you would need to take such pills regularly ), but if somebody wants to change his/her skin colour permanently and for a life, then the cheapest and easiest solution - make tattoo on the surface of the whole skin that is present on your body. I guess you could select some colour shade of a tattoo paint that will make it look beauty and healthy. But this is cheap solution for a poor. I do not know what is available for a rich people, Michael Jackson already tried something like this. Why this woman want to change her skin colour, does she believes it will look more beautiful, or she want to change relation of white people to her race?
    Well her skin is pretty sensitive,so tattooing wouldn't be a good solution,that and she's afraid of sharp things,a little butterfly tattoo,maybe,but her whole body,no way.Well,some creams are available,I made some research and hydroquinone and benoquin would be a solution,but she is really black,I mean Michael Clarke Duncan,may he rest in peace was white compared to her,so creaming and tanning everyday,is a pain in the arse.And the problem is that she wants her facial/body/hair a few shades lighter,so I figured out that direct manipulation of the melanin levels(more pheomelanin than eumelanin) would be the only solution to her problem.Basically melanocyte stimulating hormones could do that,but specifically what kind of melanocyte hormones and in what doses and in conjunction with xy drugs/hormones,so this is too broad.I also found somewhere that chloroquine can change hair color,bleach it a little,and cancer chemotherapeutic agents can do that also,but I think the safest and PERMANENT way to accomplish this is to cause a mutation of the body,so it will produce more pheomelanin than eumelanin.Or at least inhibiting the MC1R to convert pheomelanin to melanin.This mutation is relatively safe though,<span style="color: rgb(68, 68, 68); font-family: arial, sans-serif; font-size: small; line-height: 16px;">αMSH could increase pheomelanin production,but I didn't found a drug/hormone that contains it in stores.Can anybody help me out with this one,it would be really appreciated.And by the way,she wants to change her skin and hair colour(eye colour too,but for those exist surgeries,a different pot of fish)because she wants to be a completely white woman,because she thinks that is the epitome of beauty,and she wants to avoid racial discrimination(she was assaulted several times on the street).</span>
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    but I think the safest and PERMANENT way to accomplish this is to cause a mutation of the body
    Mutation of the whole body is far from safest and for now it is pure science fiction is ever will be possible.
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    Quote Originally Posted by Stanley514 View Post
    but I think the safest and PERMANENT way to accomplish this is to cause a mutation of the body
    Mutation of the whole body is far from safest and for now it is pure science fiction is ever will be possible.
    Than what would be your suggestion,besides monthly hair dying and daily creaming of the body?I'm not referring to a full-scale body mutation like in X-Men,more like increasing the level of pheomelanin,which I think wouldn't be as risky as it may sound at first.If you consider this far from safe,sure,I understand you,but the main problem with this it is too hard to accomplish at this moment.What else would you recommend?
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    What else would you recommend?
    I'm quite sure there is only one way to change colour of the skin permanently with exception of gene therapy - a tattoo. A sensitive skin is not necessarily a problem as paint delivered deeper into tissue. She may consult a specialist to know it better. There is also an interesting disease which calls Vitiligo is when a person experience depigmentation. Its reasons are still unknown, but some suggest it is caused by autoimmune, genetic, oxidative stress, neural, or viral causes. Vitiligo - Wikipedia, the free encyclopedia

    Even if somebody changes colour of skin it is still not necessarily changes external appearance specific to your race. For example looking at this African albino you still could easily tell that he doesn't look completely European. https://www.google.ca/search?hl=en&s...ml%3B640%3B480
    Last edited by Stanley514; December 27th, 2013 at 07:09 PM.
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    Quote Originally Posted by Stanley514 View Post
    What else would you recommend?
    I'm quite sure there is only one way to change colour of the skin permanently with exception of gene therapy - a tattoo. A sensitive skin is not necessarily a problem as paint delivered deeper into tissue. She may consult a specialist to know it better. There is also an interesting disease which calls Vitiligo is when a person experience depigmentation. Its reasons are still unknown, but some suggest it is caused by autoimmune, genetic, oxidative stress, neural, or viral causes. Vitiligo - Wikipedia, the free encyclopedia

    Even if somebody changes colour of skin it is still not necessarily changes external appearance specific to your race. For example looking at this African albino you still could easily tell that he doesn't look completely European. https://www.google.ca/search?hl=en&s...ml%3B640%3B480
    Well the difference is obvious yes!But there are so many aesthetical surgery options,I'm not really concerned about that lol...The tattoo idea is very ingenious,you're a smart guy(no sarcasm intended),I would never thought about that myself,to be quite frank.She will see a dermatologist and after that a professional tattooer,to see what can be done.And what about gene therapy?Can it really change skin color,or hair color?Any links would be more than welcome,in PM if the forum doesn't accept it.So,eye color,checked,skin colour checked(maybe),only hair color remains,and she is sick of dyes.You seem very knowledgeable in this topic,can you give some advice on body and facial hair color change that is permanent?Thanks alot man!
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    And what about gene therapy?Can it really change skin color,or hair color?
    Gene therapy is an emerging technology which is used in exceptional cases to cure rare genetic related diseases. Up to now there were only few thousands cases in history when it was experimentally used. It was believed to be risked and banned but recently some trials have started again. It was never used to change colour of skin or hair and I'm sure that authorities from medicine will never in foreseeable future approve it for this purpose. I have no idea if it could work even in theory for this purpose. You could read about gene therapy in Wikipedia: Gene therapy - Wikipedia, the free encyclopedia
    Principally, I would not advise to anyone to change colour of skin, since all methods to do it are risky.

    There is also a claims that:
    It is possible to lighten skin, but this is actually a medical procedure that is reserved for certain patients with a need for the procedure. That is why you should discuss you concern with a dermatologist. Some patients have a disease that affects their skin pigmentation called vitiligo. In patients who suffer from vitiligo, their immune system attacks the pigment producing cells in their skin called melanocytes. This causes them to lose all pigment from patches of skin throughout their body. Because this can leave patients with disfiguring variations in their skin pigment, medications and treatments have been developed to help even skin tone by lightening the pigmented skin areas. Lightening skin involves reducing the amount of the melanin that pigments the skin, either by decreasing its production, bleaching it away, or damaging the cells that produce pigment. The problem with these procedures is that melanin is important to your health because it is your primary protection against skin cancer. Skin whitening should only be done by a doctor, because many of the products offered over the counter have been proven to be unsafe or even toxic and can damage skin over the long term. Dermatologists typically do not offer skin whitening for purely cosmetic reasons, because it substantially increases your risk of cancer. You should bring up your concerns about your skin color to a dermatologist. They can inform you about any safe options available to lighten your skin pigment, or, more importantly, can offer counseling to help you learn to love your natural skin color. Beautiful skin comes in ALL colors, so it is far safer to work with a counselor who can help you learn to see the beauty in your own skin than to try to change it through chemicals and medications. https://www.zocdoc.com/answers/15204...or-permanently

    I think that tattoo in this regard is better since it doesn't destroy somebodie's natural pigment cells.

    You could see some interesting tattoo designs here: http://www.tattooeasily.com/face-tattoo/
    Last edited by Stanley514; December 28th, 2013 at 04:39 PM.
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    she wants to be a completely white woman,because she thinks that is the epitome of beauty,and she wants to avoid racial discrimination(she was assaulted several times on the street)
    I hope she realises that being a white woman is unlikely to reduce her chances of being assaulted on the street as much as she might hope. Her attacker(s) might have used racial epithets but people who attack women in the street will use anything as their excuse. It's true that POC are attacked more often, but virtually all women are insulted, and many are assaulted, on the street on any trivial pretext.
    "Courage is what it takes to stand up and speak; courage is also what it takes to sit down and listen." Winston Churchill
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    If this woman is rich, then I do not see why does it make a problem to her regularly purchase whitening crèmes and apply them.
    I think that someone have to be careful with a tattoo though. The problem is that skin pigmentation of an average person is not absolutely uniform across the face and body. Some patches are slightly darker, some are slightly lighter. There is plenty of micro-pimps, birthmarks, freckles, skin pores and other things which make skin look natural. Tattoo paint may look suspiciously uniform like a mask or heavily powdered face.
    If you look at this photo you will see that tattooed lipstick looks a bit unnatural on the face full of skin irregularities. http://en.wikipedia.org/wiki/Fileiana_na_2de_beh.JPG
    I hope she realises that being a white woman is unlikely to reduce her chances of being assaulted on the street as much as she might hope.
    That's true.
    Last edited by Stanley514; December 29th, 2013 at 02:55 PM.
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