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Thread: Swallowing Silver

  1. #1 Swallowing Silver 
    Moderator Moderator Cogito Ergo Sum's Avatar
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    New research indicates that silver (in the form of dissolved ions) is possibly a strong antibiotic and aids other antibiotics to disrupt bacterial cellular processes:
    "We show that silver disrupts multiple bacterial cellular processes, including disulfide bond formation, metabolism, and iron homeostasis. These changes lead to increased production of reactive oxygen species and increased membrane permeability of Gram-negative bacteria that can potentiate the activity of a broad range of antibiotics against Gram-negative bacteria in different metabolic states, as well as restore antibiotic susceptibility to a resistant bacterial strain."


    The article looks promising, because the research for and production of new antibiotics decreases whilst the number of resistant strains increases.
    Yet, is it possible that applying silver to sick patients in low quantities could cause side-effects or, as a long-term effect, increase the resistance of the bacteria one is trying to kill with the antibiotic?


    Sources:
    Silver Makes Antibiotics Thousands of Times More Effective: Scientific American
    Morones-Ramirez, J.R., Winkler, J.A., Spina, C.S. et al. (2013), "Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria", Sci. Transl. Med. 5(190), p. 190ra81
    BBC News - Antibiotics resistance 'as big a risk as terrorism' - medical chief


    "The only safe rule is to dispute only with those of your acquaintance of whom you know that they possess sufficient intelligence and self-respect not to advance absurdities; to appeal to reason and not to authority, and to listen to reason and yield to it; and, finally, to be willing to accept reason even from an opponent, and to be just enough to bear being proved to be in the wrong."

    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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  3. #2  
    Brassica oleracea Strange's Avatar
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    Argyria - Wikipedia, the free encyclopedia


    ei incumbit probatio qui dicit, non qui negat
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  4. #3  
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    Quote Originally Posted by Strange View Post
    *Some people experience some possible side effects with treatment.
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    Universal Mind John Galt's Avatar
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    Tanstaafl
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    Quote Originally Posted by John Galt View Post
    Tanstaafl
    If it's spiked with silver, I would expect it to be free.

    $100 cheeseburger.
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  7. #6  
    who sees through things
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    Medicines that work usually have side effects. You have to weigh the cost vs benefits.
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    Forum Professor river_rat's Avatar
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    Simple question, result in vivo or in vitro?
    As is often the case with technical subjects we are presented with an unfortunate choice: an explanation that is accurate but incomprehensible, or comprehensible but wrong.
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    Quote Originally Posted by Alec Bing View Post
    Medicines that work usually have side effects. You have to weigh the cost vs benefits.
    I was being facetious above- just for the record.

    Personally, I have very strong doubts as to whether silver can medically be used as an anti-biotic. Now, a scientific American article does seem to disagree with me- But in the last few years, Scientific American appears to have also become a mag version of the Discovery channel.

    I mean... Lava is one hell of an anti-biotic too.
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  10. #9  
    Moderator Moderator Cogito Ergo Sum's Avatar
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    Quote Originally Posted by river_rat View Post
    Simple question, result in vivo or in vitro?

    Both.
    In vivo tests were performed in mouse models.
    "The only safe rule is to dispute only with those of your acquaintance of whom you know that they possess sufficient intelligence and self-respect not to advance absurdities; to appeal to reason and not to authority, and to listen to reason and yield to it; and, finally, to be willing to accept reason even from an opponent, and to be just enough to bear being proved to be in the wrong."

    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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  11. #10  
    has lost interest seagypsy's Avatar
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    But if you are a werewolf it will just kill you.
    Speaking badly about people after they are gone and jumping on the bash the band wagon must do very well for a low self-esteem.
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  12. #11  
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    Personally, I have very strong doubts as to whether silver can medically be used as an anti-biotic.
    Silver is used in some burns dressings to control infections.

    Victorian Burns Unit
    "Courage is what it takes to stand up and speak; courage is also what it takes to sit down and listen." Winston Churchill
    "nature is like a game of Jenga; you never know which brick you pull out will cause the whole stack to collapse" Lucy Cooke
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    I said I have doubts- never said I was right
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    According to a friend of mine, it really works. (however, he runs the company that makes it) They are working on ways to enhance the structure so it can get everywhere more quickly, so the dosage can be lower, and will have fewer side effects.

    However, i'm really sceptic about this.

    Below, a picture about what it looks like..

    Growing up, i marveled at star-trek's science, and ignored the perfect society. Now, i try to ignore their science, and marvel at the society.

    Imagine, being able to create matter out of thin air, and not coming up with using drones for boarding hostile ships. Or using drones to defend your own ship. Heck, using drones to block energy attacks, counterattack or for surveillance. Unless, of course, they are nano-machines in your blood, which is a billion times more complex..
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  15. #14  
    who sees through things
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    People have been using colloidal silver as a supplement for its antibiotic properties for a long time. Should be interesting if the pharma company tries to patent the use of silver as an antibiotic.
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  16. #15  
    Forum Radioactive Isotope skeptic's Avatar
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    Colloidal silver taken internally is well recognised as a quack remedy. The quacks, of course, push it hard, and make extravagant claims. It would make sense to use silver in a poultice or similar, where its effect was topical. However, that is very different to ingesting it.
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  17. #16  
    who sees through things
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    Quote Originally Posted by skeptic View Post
    Colloidal silver taken internally is well recognised as a quack remedy. The quacks, of course, push it hard, and make extravagant claims. It would make sense to use silver in a poultice or similar, where its effect was topical. However, that is very different to ingesting it.
    This is what happens when you respond to the title of the thread rather than the linked article and you don't want to pay for the full research study, with methods.
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  18. #17  
    Theatre Whore babe's Avatar
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    Quote Originally Posted by Neverfly View Post
    Quote Originally Posted by Alec Bing View Post
    Medicines that work usually have side effects. You have to weigh the cost vs benefits.
    I was being facetious above- just for the record.

    Personally, I have very strong doubts as to whether silver can medically be used as an anti-biotic. Now, a scientific American article does seem to disagree with me- But in the last few years, Scientific American appears to have also become a mag version of the Discovery channel.

    I mean... Lava is one hell of an anti-biotic too.
    I have tried the silver stuff...friend made it....and it actually did help a lot.

    As for llva as one hell of an antibiotic...*chuckle* well living in Hawai'i on BI, I breath enough of it daily and am surrounded by it. If it is medicinal....that I do not know, but I do know I rarely get sick.

    I personally think it is the sunshine and the ocean.

    It has certainly helped me.
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  19. #18  
    Theatre Whore babe's Avatar
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    Quote Originally Posted by seagypsy View Post
    But if you are a werewolf it will just kill you.
    very funny
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  20. #19  
    Moderator Moderator Cogito Ergo Sum's Avatar
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    Update

    Two teams of chemists have figured out how to make stable silver nanoparticles on a large scale.

    Apart from the possible applications in solar cells, it is also relevant to this thread:
    "(...) Bigioni and Zheng's procedures made only particles with 44 metal atoms, no more or less. Not only does this make it easy to purify the particles, says Bigioni, but it would also make the properties and quality of the particles much more predictable, easing the path to regulatory approval for any biomedical uses of the particles, such as delivering antibiotic silver atoms to a microbe."
    (cf. Easy route to stable silver nanoparticles : Nature News & Comment)
    "The only safe rule is to dispute only with those of your acquaintance of whom you know that they possess sufficient intelligence and self-respect not to advance absurdities; to appeal to reason and not to authority, and to listen to reason and yield to it; and, finally, to be willing to accept reason even from an opponent, and to be just enough to bear being proved to be in the wrong."

    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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  21. #20  
    Brassica oleracea Strange's Avatar
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    Quote Originally Posted by Alec Bing View Post
    People have been using colloidal silver as a supplement for its antibiotic properties for a long time. Should be interesting if the pharma company tries to patent the use of silver as an antibiotic.
    As it is already widely used, it can't be patented. Novel methods of manufacturing and/or delivering it could be.
    ei incumbit probatio qui dicit, non qui negat
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  22. #21  
    Forum Sophomore Nisslbody's Avatar
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    The fact that silver is an antimicrobial agent is not exactly new news. Antibacterial Silver

    The part which is new is the investigation of the mechanism by which silver is more toxic to bacteria than to human cells. Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria
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  23. #22  
    Moderator Moderator Cogito Ergo Sum's Avatar
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    Quote Originally Posted by Nisslbody View Post
    The part which is new is the investigation of the mechanism by which silver is more toxic to bacteria than to human cells. Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria

    That is, more or less, my thread in a nutshell.
    Nisslbody likes this.
    "The only safe rule is to dispute only with those of your acquaintance of whom you know that they possess sufficient intelligence and self-respect not to advance absurdities; to appeal to reason and not to authority, and to listen to reason and yield to it; and, finally, to be willing to accept reason even from an opponent, and to be just enough to bear being proved to be in the wrong."

    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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