Notices
Results 1 to 1 of 1

Thread: Metformin: A possible drug for treatment of endometrial cancer

  1. #1 Metformin: A possible drug for treatment of endometrial cancer 
    New Member
    Join Date
    Dec 2012
    Posts
    1
    Metformin is a widely used first-line drug for treatment of type 2 diabetes mellitus. In recent years, it has been reported that administration of metformin can reduce carcinogenic risk and inhibit proliferation of cancer cells including those from glioma and breast cancer. The underlying mechanism is thought to involve increased LKB-1 phosphorylation induced by metformin, followed by LKB-1 phosphorylation and activation of AMP-activated protein kinase (AMPK), which then inhibits the mammalian target of rapamycin (mTOR) pathway and results in inhibition of cell proliferation. In endometrial cancer, metformin causes cell cycle arrest in vitro, reduces hTERT mRNA, inhibits the mTOR pathway via AMPK, and is involved in inhibition of phosphorylation of S6 ribosomal protein (S6RP). Metformin promotes expression of progesterone receptor by an action opposite to that of insulin-like growth factor-2 (IGF-2) when used in combination with medroxyprogesterone acetate. This enhances the antitumor effect and this approach may be applicable in a clinical setting.

    see the full paper,plese click:OJOG_Medicine & Healthcare_Journal_SCIRP



    Reply With Quote  
     

  2.  
     

Similar Threads

  1. Replies: 0
    Last Post: January 9th, 2012, 01:31 AM
  2. US proposed cancer drug reserve
    By iceaura in forum Business & Economics
    Replies: 2
    Last Post: September 3rd, 2011, 05:21 PM
  3. Henry's Law in the treatment of Cancer
    By pichi2078 in forum Chemistry
    Replies: 1
    Last Post: October 12th, 2009, 12:14 PM
  4. Wastewater treatment
    By andrefonsecaa in forum Environmental Issues
    Replies: 2
    Last Post: July 12th, 2009, 03:26 PM
  5. Cancer, gene therapy and cancer stem cells
    By gottspieler in forum Biology
    Replies: 4
    Last Post: December 31st, 2008, 09:58 AM
Bookmarks
Bookmarks
Posting Permissions
  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •