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Thread: About Vitamin K1 stability

  1. #1 About Vitamin K1 stability 
    New Member
    Join Date
    Jan 2010
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    2
    Vitamin K1 injection stability…
    ” Stable to air and moisture, but decomposes in sunlight. Unaffected by dilute acids, but is destroyed by solutions of alkali hydroxides and by reducing agents”

    But when we kept in a cool dry place where the temperature stays below 25 °C. Its color still change and assay of phytomenadione is decreasing.
    Ingredients including: Propylene Glycol, Tween 80, Acetic Acid Glacial, Water for Injection. And ampoule treat by ammonium sulfate.

    Any one could give me any suggestion?


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  3. #2 Re: About Vitamin K1 stability 
    Time Lord
    Join Date
    Apr 2008
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    5,328
    ” Stable to air and moisture, but decomposes in sunlight.
    This means ultraviolet, as from fluorescent lighting.


    A pong by any other name is still a pong. -williampinn
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  4. #3  
    New Member
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    Jan 2010
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    yes i know it will decomposes from fluorescent lighting...
    So vitamin k1 fillin amber amp.,but it still decomposed
    Acutally i doubt "alkali hydroxides" is root cause...
    i just don't know what part of proceeing is problem and how to avoid it.... >:
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