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Thread: Can you alter chromosome after birth

  1. #1 Can you alter chromosome after birth 
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    Is it possible to alter one's chromosomes after birth?


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  3. #2  
    Forum Cosmic Wizard spuriousmonkey's Avatar
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    yes.

    The standard way is to make gametes and then fuse them with other ones.


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  4. #3 Re: Can you alter chromosome after birth 
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    Quote Originally Posted by drdede
    Is it possible to alter one's chromosomes after birth?
    Read up on gene therapy. Some forms allow us to perform integration, in which new genetic material is inserted into a chromosome. Viral gene therapy vectors such as AAV can (sometimes) allow integration into very specific sites on specific chromosomes.

    Quote Originally Posted by spuriousmonkey
    yes.

    The standard way is to make gametes and then fuse them with other ones.
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  5. #4 Re: Can you alter chromosome after birth 
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    Quote Originally Posted by TheBiologista
    Read up on gene therapy. Some forms allow us to perform integration, in which new genetic material is inserted into a chromosome. Viral gene therapy vectors such as AAV can (sometimes) allow integration into very specific sites on specific chromosomes.
    Has this ever actually worked? So far as I know it has never really been successful. (Although I certainly might be wrong about that, I haven't really been paying attention that closely).
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  6. #5  
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    I think Gene therapy has been somewhat successful, but one of the problems with the one case I have looked at was the development of leukemia, which I gather was due to insertion of the genetic material causing a mutation.

    How is it that AVV can insert specifically? (curiosity)
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    As I recall the closest they ever got to real success was with a group of people who had some freaky metabolic disorder that was caused by a missing gene. They were able to get the disorder to reverse itself for a while, but it eventually came back. In many of the other trials it either killed the patients or just didn't seem to do anything. Still, the principle seems pretty sound.
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  8. #7  
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    There have been few cases of success. After Jesse Gelsingers tragic death, a lot of trials were halted and re thought.

    The case I was referring too was where patients (less than a year old I think) were treated to correct a mutation resulting in Severe combined immunodeficiency X1 disorder. After 10 months they seemed to have corrected the disease phenotype, but later died from Leukemia. Iím sorry I cannot provide a link to the trial.

    Another case which may be interesting for a look up may be the injection of naked DNA for VEGF used to treat critical limb ischemia and is in a phase 1 trial for Motor Neuron Disease, again no links, this is from my classes. The treatment of limb ischemia has shown long lasting effects.
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  9. #8  
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    Cool, I'm glad someone actually got it to work.
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  10. #9  
    sai
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    by observing some people i wish toa sk a question that isit not possible to completly transform a biological male/female to opposite gender ,if not why? plz answer to my question
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  11. #10  
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    Quote Originally Posted by sai View Post
    by observing some people i wish toa sk a question that isit not possible to completly transform a biological male/female to opposite gender ,if not why? plz answer to my question
    It is not possible. The task is far too complex. To make such a transformation every body cell would have to have a Y chromosome inserted and an X chromosome removed to make the female become male, or the reverse to make the male become female. We can surgicaly make a male look like a female externally but the person remains their birth gender at a cellular level. Transgenered persons can't reproduce.
    This is interesting because in some species functional reversal of gender is not only possible but routine.
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  12. #11  
    Forum Radioactive Isotope cosmictraveler's Avatar
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    Quote Originally Posted by sai View Post
    by observing some people i wish toa sk a question that isit not possible to completly transform a biological male/female to opposite gender ,if not why? plz answer to my question

    Why?
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  13. #12  
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    Last edited by Stanley514; September 6th, 2017 at 10:17 PM.
    Antislavery
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  14. #13  
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    Not to get into the discussion of "brain Gender".
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