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Thread: Prostate Cancer

  1. #1 Prostate Cancer 
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    Is is efficient way of finding if one have prostate cancer by doing psat test on patient? How sure can the procedure be to find out what stage of prostate one might have.

    here is what psat really does but I still wander how efficient it can be. Prostate-specific antigen (PSA) is a protein produced by the cells of the prostate gland. The PSA test measures the level of PSA in the blood. The doctor takes a blood sample, and the amount of PSA is measured in a laboratory. Because PSA is produced by the body and can be used to detect disease, it is sometimes called a biological marker or tumor marker.

    It is normal for men to have low levels of PSA in their blood; however, prostate cancer or benign (not cancerous) conditions can increase PSA levels. As men age, both benign prostate conditions and prostate cancer become more frequent. The most common benign prostate conditions are prostatitis (inflammation of the prostate) and benign prostatic hyperplasia (BPH) (enlargement of the prostate). There is no evidence that prostatitis or BPH causes cancer, but it is possible for a man to have one or both of these conditions and to develop prostate cancer as well.

    PSA levels alone do not give doctors enough information to distinguish between benign prostate conditions and cancer. However, the doctor will take the result of the PSA test into account when deciding whether to check further for signs of prostate cancer.

    By doing PSAT one can do get wrong therapies and what are the side effect..


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  3. #2 Re: Prostate Cancer 
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    Quote Originally Posted by sondivp456
    PSA levels alone do not give doctors enough information to distinguish between benign prostate conditions and cancer. However, the doctor will take the result of the PSA test into account when deciding whether to check further for signs of prostate cancer.
    Without me doing much research, I think you answered your own question. It would be considered a good screening type as high levels of PSA would suggest a disease state, possibly cancer. Of course other diagnostic methods would have to be employed to prove this. Due to the false positives which can occur, this may be damaging, granted.

    But a lot of cancer deaths are as a result of secondary tumors formed as the original tumor cells become mobile (metastasis) and spread to other organs. PSA testing is a good way to detect possible prostate cancer in males and thus could prevent loss of life. Of course the decision to treat any cancer that is definite would not be taken lightly.

    Quote Originally Posted by sondivp456
    By doing PSAT one can do get wrong therapies and what are the side effect..
    I donít quite understand you here. Are you asking about misdiagnosis of prostate cancer and the side effects of cancer treatment, or the side effects of biopsy and other methods used to determine if there cancerous tissue present?
    A useful Ref. http://<a href="http://www.cancer.go...ection/PSA</a>


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  4. #3  
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    What he means is that PSA is a relative measurement; a high PSA is not absolutely diagnostic of prostate cancer & there is evidence that many men undergo prostatectomies unnecessarily.

    This may be due to misdiagnosis by the PSA which is unusualy these days as it is usually followed with further testing. Or it may be that there are low grade malignant cells which grow at too slow a rate to allow the disease threaten the patients life; the majority of patients who develop prostate cancer do not die of the condition.

    The major side effects of prostatectomy which causes public concern is impotence and incontinence which have high morbidity burdens; you do not want this surgery unless you absolutely have to.
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  5. #4  
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    Quote Originally Posted by Robbie
    Or it may be that there are low grade malignant cells which grow at too slow a rate to allow the disease threaten the patients life; the majority of patients who develop prostate cancer do not die of the condition.
    Thatís an interesting point. So is there no way to determine that the carcinoma is progressing slowly without removing it or taking a biopsy?

    Would that mean that it comes down to the decision Ė chance that it is not and will not become aggressive and metastatic or operate and risk the complications?

    I understand that itís not a definitive diagnostic and it is a relative measurement, but as a screening procedure I think it is still quite efficient - suggesting a cancer is present and providing a chance to take decisive action?
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  6. #5  
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    "Thatís an interesting point. So is there no way to determine that the carcinoma is progressing slowly without removing it or taking a biopsy?"

    thats correct.
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  7. #6  
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    Well radiologically you can have an idea; but know; the only way you can know the characteristics of the cells is to look at the cells themselves.

    Yes there is a chance that it may become more aggressive etc; but generally you can predict quite accurately the chance of progression.
    The real issue is that if you have a 75 year old with possible prostate cancer; do u operate? Is he going to live long enough for the disease to threaten his life? And even if it will; is it worth the morbidity of the operation?
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  8. #7  
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    So it really is a case of judgment of the doc as to what kind of decisive action to take. I guess if the guy is happy to live out the remainder of his life and bow out at the end of the show, then so be it.

    But a PSA test allows for the choice to investigate to be made.

    Thanks for the discussion lads,
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