Thread: regeneration?

Is anything breakthough on tissue regeneration of any organs in our bodies or tissue in general or nerves? How about ligaments of the body. I'm assuming there isn't much information by looking around online. But I just wanted to ask people here who probably research even more than me. I'm so sad right now as I feel like there is nothing I can do anymore to heal my broken organs tissues/nerves or ligaments of my body. I know even if there is some research being done by the time they make something it'll be when I can no longer fix my problem or well when I'm too old to care anymore. But please if you guys know any information or can point me to where I can find it, it would be greatly appreciated.

Tissue regeneration advancements are on the way with stem cell research. Hang in there. We have learned a lot from newts and the axolotyl. When newts lose a limb, the epidermis migrates to cover the stump after about 12 hours, forming a structure called the apical epidermal cap (AEC). Over the next several days a blastema (a mass of dedifferentiated proliferating cells) forms. As the blastema forms, pattern formation genes (HoxA and HoxD, for instance) are activated as they were when the limb was formed in the embryo. Inducing a cell that wasn't a controversial embryonic stem cell to such a state was difficult in the past but Shinya Yamanaka's IPSCs (induced pluripotent stem cells) have changed that. Although one of the transfected retroviruses (c-myc) used made tumors likely to develop in tissues, another scientist Konrad Hochedlinger at Harvard recently successfully used an adenovirus to transport the requisite four genes into the DNA of skin and liver cells of mice, resulting in cells identical to embryonic stem cells. Since the adenovirus does not combine any of its own genes with the targeted host, the danger of creating tumors is eliminated. This has, however, not yet been tested on human cells. We already know at least some form of regeneration.The liver and skin cells are unipotent cells that can self-renew, or regenerate upon injury.

thank you so much. this is both uplifting and sad. Uplifting because there are advancements but since it's never been used on humans, I'm thinking it probably isn't safe or workable on humans. I'm so scared. I just want my body to heal. I know it won't be possible soon enough sadly. I wish I was younger. I also wish I didn't put myself in this situation. But thanks for being so kind to answer my question. It was very nice of you.

Clinical trials are starting on stem cell research to repair spinal injuries, however they are just Phase 1 trials, which means they aren't looking to see if it works, but just if putting stem cells into people's spines causes death or not.

I see thanks. Does this test for if stem cells kill someone regardless of where it's placed or is this a test just to see if it won't kill someone if they are placed at the spinal cord?

Like if it works it doesn't mean it would work if they placed the stem cells on the bladder or kidney right?

Ya exactly, neural tissue happens to be a kind of default state for embryonic stem cells to go towards, so the easiest tissues to produce with stem cells is neural tissue. There is research being done in other fields though, but none as far as long as the neural stuff to repair damage from strokes or spinal cord damage.

Edit: They'll be looking specifically for adverse effects in the spine, if positive effects occur too that's good news, but they aren't specifically looking for positive effects yet.

Okay I know I sound silly, but I just wanted to make sure so if there are adverse effects on the spine and then that means there are adverse effects on other body parts? And if it was positive effects on the spine then positive effects on the rest of the body?
If they can't do anything for the spine they can do it for other parts of the body like a kidney or is that not available?

No they would have to develop something completely different.

And a new procedure working on kidneys would have to undergo a completely new clinical trial. The clinical trial process can take up to 10 years before anything gets approved for use on people, we're a long way off from being able to repair a kidney using stem cells.

Oh okay I understand now. thanks. Sigh I wish I was younger. I want to thank all the scientist and researchers for at least being able to help the new generation.

Originally Posted by crazyscientist

Oh okay I understand now. thanks. Sigh I wish I was younger. I want to thank all the scientist and researchers for at least being able to help the new generation.

Just try to do whatever you can until the day comes. Who knows what the future will bring?

Originally Posted by crazyscientist

I I'm assuming there isn't much information by looking around online.

So far this year there have been only 396 publications on this topic.

I found out by looking around online.