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Thread: Hyaluronic Acid Solubility

  1. #1 Hyaluronic Acid Solubility 
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    I am working on a project that involves the use of Hyaluronic Acid. Does anyone have any experience dissolving Hyaluronic Acid in anything besides water? If so, what solvent was used?


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    Forum Freshman sp1der's Avatar
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    Hyaluronic acid will only dissolve in water.


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    Bullshit Intolerant PhDemon's Avatar
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    Is it the acid or its sodium salt? If the latter I think it is soluble in glycerol, propylene glycol and to a limited degree ethanol.
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    Quote Originally Posted by PhDemon View Post
    Is it the acid or its sodium salt? If the latter I think it is soluble in glycerol, propylene glycol and to a limited degree ethanol.
    We are working with the actual acid, not the sodium salt. I was able to dissolve it in Glycerol up to 1% by applying heat through a magnetic stirrer, which I believe would be called esterfication. I was hoping to dissolve the hyaluronic acid up to 10%, so if you have any suggestions let me know. My only thought was to use a hyaluronic acid with lower molecular weight.
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    Bullshit Intolerant PhDemon's Avatar
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    Yes, the actual acid may react with alcohols rather than dissolve in them... Have you tried acetone? Alternatively could you use the sodium salt rather than the acid?
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  7. #6  
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    Quote Originally Posted by PhDemon View Post
    Yes, the actual acid may react with alcohols rather than dissolve in them... Have you tried acetone? Alternatively could you use the sodium salt rather than the acid?
    No, we have not tried the sodium salt yet, but that might be the next step. Will the sodium salt dissolve in glycerol at a higher concentration/ without a reaction taking place? Acetone is something we cannot use for this project.
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  8. #7  
    Bullshit Intolerant PhDemon's Avatar
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    It's not something I've used before but here is the data sheet I used when I answered your question:

    http://shop.copaiba.info/component/v...product_id=104

    The sodium salt shouldn't react with the alcohol groups of glycerol as it is a salt not an acid.
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