first post here, but with a problem I can't realy figure out.
When you look at biodegradable polymers like PLA, PGA and PCL, you see that they have a different degradation rate.
From slow to fast degradation it goes like this: PCL < PLA < PGA.
Could someone please explain me, based on the structures why they degrade (slow to fast) in this order?
The way I see it (can't ask a question without some research ofcourse):
- PCL is very hydrophobic due to the 5 -CH2- groups it contains, thus in an aqueous situation, hydrolysis will be more difficult.
- The difference between PLA and PGA: does the CH3 group on the PLA-sidechain exert a hypercojugating effect towards the labile bond that's cleaved in ester hydrolysis? Or is there another explanation?
Can someone plz clear this out for me?
Thx in advance!