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Thread: Free Radicals and the ageing process

  1. #1 Free Radicals and the ageing process 
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    i was wondering what free radicals are said to cause ageing.
    is there any proof, my book just says they think , but its a learn all memory book!
    is there any web based research site or info? anyone here interested in the topic?

    last point, is this chem or bio, or biochem? not sure where i should post!


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  3. #2  
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    Indeed radicals cause aging; certainly they cause aging diseases (like diabetes). Radicals are highly reactive molecules they can bind your DNA causing mutation in your DNA (wrong transcription or replication). They also react with other cell molecules like your enzymes and fats.
    Normally your cells have different mechanisms to repair DNA damage. These repair systems are less active in older people making them more sensitive to radicals.

    Others have suggested that vitamin E rich diet (an essential vitamin and cofactor in DNA repair) would slow down many age-linked-diseases.
    Also eating lots of vitamine C is suggested to help because it neutralises free radicals.

    Maybe an extra thought and this topic is ready for the Philosophy section.
    Cells have endless life. My sperm cell together the ovule of my wife makes new cells that can divide. My 27 year old cells can be programmed to become fresh ones of new born child.
    So if scientist (and I hope they never do) can find how this mechanism works (which enzyme must be activated) then endless life is possible…………


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    old age diabetes? that type one ?

    right, so its mainly the dna. what bout the idea of ingesting any other than vit c, chemical or compound to counter those free radicals, is that a sound theory or is it just talk.

    do the free-radicles damage dna during the mRNA process? or do they disrupt the hyrogen bonding between bases?

    what free-radicles are the most common in the body? or is there too manY to count?

    my knowalage of free radicles end at the part played in the atmosphere and the formation of chlormethane! (uv ligth splitting the chlorine, so the free-rad can attack the methane)

    im also interested in free-radicals in the atmosphere, cant we fill t atmos so the O3 wont be destroyed by free radicles.
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    Quote Originally Posted by goodgod3rd
    old age diabetes? that type one ?

    Indeed Old age diabetes (type 2)

    Quote Originally Posted by goodgod3rd
    right, so its mainly the dna. what bout the idea of ingesting any other than vit c, chemical or compound to counter those free radicals, is that a sound theory or is it just talk.
    The theory is in progess but certain facts do hold.

    Here is a popular link, google or pubmed the names of the reachers will get you started into further reading.
    http://news.bbc.co.uk/2/hi/health/4520727.stm

    Can’t think of any other right know, (oh yeah the health of red wine (no more then one glass a day) is suggested to be also anti-oxidant of function (trapping free radicals). Regarding the red wine, a paper in “science” told that the talines in wine triggered certain genes which could -when overexpressed in mice- prolong life. So the health qualities of wine might be other then anti-oxidant. So red wine is a bad example.

    Quote Originally Posted by goodgod3rd
    do the free-radicles damage dna during the mRNA process? or do they disrupt the hyrogen bonding between bases?
    To my knowledge they can damage DNA at any timepoint (by reaction with the bases resulting in altered H-bond patterns resulting in different base affinity), as a result the modified base can account for wrong transcription (which would result in wrong mRNA) or wrong replication which will result in a more permanent mutation.

    Quote Originally Posted by goodgod3rd
    what free-radicles are the most common in the body? or is there too manY to count?

    Most radicals that damage your cell come from your respiration. (In the mitochondria O2 is used as the final acceptor in the electron flow ultimately to generate energy (ATP). Someone can correct me, but I think mainly hydroxyl radicals are formed.
    So people with a high respiration tend have shorter lives. With older age the mitochondria get more leaky and more easily release the radicals (this combination with lower enzymes that counter free radicals in the cell results in damaged DNA en later cell processes, followed by deseases).


    Quote Originally Posted by goodgod3rd
    my knowalage of free radicles end at the part played in the atmosphere and the formation of chlormethane! (uv ligth splitting the chlorine, so the free-rad can attack the methane)

    im also interested in free-radicals in the atmosphere, cant we fill t atmos so the O3 wont be destroyed by free radicles.
    Here we need third party.
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  6. #5  
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    cheers, thats great!

    thanks,
    ok, sorry bout the jumbled O3 thing! lol,

    i meant


    im also interested in free-radicals in the atmosphere, cant we fill the atmosphere with free radicle exceptors so the O3 wont be destroyed by free radicles.
    if anyone can asnwer , please do so!
    Stumble on through life.
    Feel free to correct any false information, which unknown to me, may be included in my posts. (also - let this be a disclaimer)
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