Notices
Results 1 to 6 of 6

Thread: help with units and toxicity

  1. #1 help with units and toxicity 
    Forum Freshman
    Join Date
    Feb 2007
    Location
    cambridge, uk
    Posts
    16
    i want to be able to find out whether or not cadmium compound present at a certain volume and at a certain concentration would be toxic and dangerous or not. well infact, i know it probably isnt but i want to know how far off it is

    so i have 30ul at a concentration of 100ppm (mg/L)
    this is inhaled, and the LD50 units for this are in mg/m3/2-hour
    how can i make my data comparable with this?


    Reply With Quote  
     

  2.  
     

  3. #2  
    Forum Ph.D.
    Join Date
    Jan 2009
    Posts
    951
    LD50 referrs to the body burden concentration from whch 50% of the test subjects
    die usually expressed in mg/Kg or ugm/Kg for highly toxic stuff.
    your units are not LD50 units but limits for airborne exposure. Youwould lookup the LD50 for Cd and then caculate how long it woud take to inhale this amount ofCd , also assuming some body weight in Kgs


    Reply With Quote  
     

  4. #3  
    Forum Freshman
    Join Date
    Feb 2007
    Location
    cambridge, uk
    Posts
    16
    The amount i have specified above is the amount and concentration used to lace a cigarette. Accounting for loss of cadmium in smoke not inhaled and cadmium not absorbed in the lungs, i have worked out 8ul (roughly) will be absorbed.
    I guess this will be over the course of a couple of minutes, the time it takes to smoke a cig, so how can i compare this with LD50 values!!??
    Reply With Quote  
     

  5. #4  
    Forum Ph.D.
    Join Date
    Jan 2009
    Posts
    951
    sorry but I really don't understand the questionat this point.
    Reply With Quote  
     

  6. #5  
    Forum Ph.D.
    Join Date
    Feb 2005
    Location
    Dublin, Ireland
    Posts
    945
    What you should do is make the concentration of you have (say your cig conc.) into the same units as your quoted LD50 value.

    That is assuming that the absorption is into one compartment and stays at that concentration. Essentially the LD50 is a comparative amount. You have your theoretical concentration of toxin absorbed, so you can directly compare the two.

    If this is a project or just interest or anything, might be an idea to have a think about distribution of the toxin once in the plasma (will it be protein bound, deposit in the adipose tissue?), metabolism and excretion. these can greatly affect the toxic effects of any compound.
    Stumble on through life.
    Feel free to correct any false information, which unknown to me, may be included in my posts. (also - let this be a disclaimer)
    Reply With Quote  
     

  7. #6  
    Forum Ph.D.
    Join Date
    Jan 2009
    Posts
    951
    .000030 L X 100 mg/L= .0030 mg 0r .000003 gm
    3 ugm of Cd is not a harmfull dose, however prolonged accumilation will occur with contiinued smoking
    Still don't know where this is going, is this for atoxicolgy class?
    ?
    Reply With Quote  
     

Bookmarks
Bookmarks
Posting Permissions
  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •