# Thread: help with units and toxicity

1. i want to be able to find out whether or not cadmium compound present at a certain volume and at a certain concentration would be toxic and dangerous or not. well infact, i know it probably isnt but i want to know how far off it is

so i have 30ul at a concentration of 100ppm (mg/L)
this is inhaled, and the LD50 units for this are in mg/m3/2-hour
how can i make my data comparable with this?

2.

3. LD50 referrs to the body burden concentration from whch 50% of the test subjects
die usually expressed in mg/Kg or ugm/Kg for highly toxic stuff.
your units are not LD50 units but limits for airborne exposure. Youwould lookup the LD50 for Cd and then caculate how long it woud take to inhale this amount ofCd , also assuming some body weight in Kgs

4. The amount i have specified above is the amount and concentration used to lace a cigarette. Accounting for loss of cadmium in smoke not inhaled and cadmium not absorbed in the lungs, i have worked out 8ul (roughly) will be absorbed.
I guess this will be over the course of a couple of minutes, the time it takes to smoke a cig, so how can i compare this with LD50 values!!??

5. sorry but I really don't understand the questionat this point.

6. What you should do is make the concentration of you have (say your cig conc.) into the same units as your quoted LD50 value.

That is assuming that the absorption is into one compartment and stays at that concentration. Essentially the LD50 is a comparative amount. You have your theoretical concentration of toxin absorbed, so you can directly compare the two.

If this is a project or just interest or anything, might be an idea to have a think about distribution of the toxin once in the plasma (will it be protein bound, deposit in the adipose tissue?), metabolism and excretion. these can greatly affect the toxic effects of any compound.

7. .000030 L X 100 mg/L= .0030 mg 0r .000003 gm
3 ugm of Cd is not a harmfull dose, however prolonged accumilation will occur with contiinued smoking
Still don't know where this is going, is this for atoxicolgy class?
?

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