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About LinkBacks[quote]An education isn't how much you have committed to memory, or even how much you know. It's being able to differentiate between what you know and what you don't.
Anatole France
April 25th, 2008, 10:01 AM
[quote]An education isn't how much you have committed to memory, or even how much you know. It's being able to differentiate between what you know and what you don't.
Anatole France
I suspect newbie error... :?
oh no.
u know..enzymes play role in aging..it has been proved in plants..
we all know abt telomerase...which is an enzyme that plays role during cell division....keeps cells young...but one condition is there...what is it..let me know guys...
....or not.
I don't. Why don't you tell me?Originally Posted by biotoy
some trees live for more than hundred years...how is it possible...how this happens...some scientists says that it is because of this enzyme...telomerase...and they say that...when this enzyme maintained in constant level...cells are not aging...is this possible for humans...and what is the mechanisms behind this.. 8)
Unfortunately when telomerase is misexpressed in humans it usually leads to cancer.
@Obviously
Telomerase is an enzyme that extends the telomeres which are lengths of unexpressed DNA at the ends of chromosomes. When chromosomes are replicated a bit of the telomere is knocked off everytime. A prominent theory in what causes senescense is that cells will stop replicating once the telomeres get too short.
This isn't the whole picture of what causes aging though. After all your brain cells aren't replicating yet they are still aging. More significant is probably general damage to the mitochondrial DNA from superoxide free radicals, and other damage to the genome that accumulates with time.
They were able to extend the life of mice by 40% too by restricting caloric intake to the bare minimum needed for survival.
Yes Biotoy trees have these long clocks in proportion to their generations. Telomerase is a clock, the clock, it appears. So we've found the human aging clock, and may set it at will. We even know how to make it self-winding - immortality and no batteries required.
It's ugly though, because if used for immortality the body essentially becomes one enormous benign tumor. Not good. Would you eat cow brains if starving for protein?
Our first practical application (I hope) will be to accelerate replication losses, in existing cancer cells. Not the other way around.
according to this site telomerase can be helpful for continuous cell division...but it would not lead to cancer...but we have to consider other factors like oxidative stress, glycation and telomere shortening..etc..which involved in aging
That is of almost no relevance in the lab for any kind of intervention though.
It is more likely to be dangerous/carcinogenic whatever you're thinking of. And what are you thinking of? If you want to activate telomerase then your thinking of dividing cells for what? Growing? Pathology has quite little to do with this except in cancer.
Telomerase prevents telomere shortening like you said as an other factor.
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