Thread: Barr bodies and sex-linked genetic diseases

With regards to Barr Bodies in human females, what are the consequences for sex-linked diseases (i.e. haemophilia)? Should we not expect heterozygous females to show partial symptoms of the disease in question, due to one allele being active in certain parts of the body and the other allele being active in different parts?

No, generally for some unknown mechanism, the "faulty" or pathological chromosome is turned off (that's the reason women are not as susceptible to Fragile X Syndrome) , as far as I know, this occurs in the embryo so that the same chromosome is turned off throughout the body as it develops.

Originally Posted by Robbie

No, generally for some unknown mechanism, the "faulty" or pathological chromosome is turned off (that's the reason women are not as susceptible to Fragile X Syndrome) , as far as I know, this occurs in the embryo so that the same chromosome is turned off throughout the body as it develops.

Thanks very much for the insight. I was having trouble finding information on this.