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Thread: Barr bodies and sex-linked genetic diseases

  1. #1 Barr bodies and sex-linked genetic diseases 
    Forum Freshman adamd164's Avatar
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    With regards to Barr Bodies in human females, what are the consequences for sex-linked diseases (i.e. haemophilia)? Should we not expect heterozygous females to show partial symptoms of the disease in question, due to one allele being active in certain parts of the body and the other allele being active in different parts?


    Knowledge of evolution may not be strictly useful in everyday commerce. You can live some sort of life and die without ever hearing the name of Darwin. But if, before you die, you want to understand why you lived in the first place, Darwinism is the one subject that you must study.

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  3. #2  
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    No, generally for some unknown mechanism, the "faulty" or pathological chromosome is turned off (that's the reason women are not as susceptible to Fragile X Syndrome) , as far as I know, this occurs in the embryo so that the same chromosome is turned off throughout the body as it develops.


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    Forum Freshman adamd164's Avatar
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    Quote Originally Posted by Robbie
    No, generally for some unknown mechanism, the "faulty" or pathological chromosome is turned off (that's the reason women are not as susceptible to Fragile X Syndrome) , as far as I know, this occurs in the embryo so that the same chromosome is turned off throughout the body as it develops.
    Thanks very much for the insight. I was having trouble finding information on this.
    Knowledge of evolution may not be strictly useful in everyday commerce. You can live some sort of life and die without ever hearing the name of Darwin. But if, before you die, you want to understand why you lived in the first place, Darwinism is the one subject that you must study.

    ~ Richard Dawkins
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