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Thread: Lamin A

  1. #1 Lamin A 
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    I was reading an article today about a protein called Lamin A. From what I read the protein coats the outside of a cell's nucleus. Lamin A starts out as prelamin A, and the presence of an enzyme called Zmpste 24 matured the prelamin A into Lamin A. The DNA of cells has been found to repair properly when Lamin A is healthy, but any type of mutation will interupt this repair and cause aging to proceed. They are now developing inhibitors to the enzyme that would interupt the production of Lamin A and in cancerous cells and/or tumors cause aging and death of the cells. Yeah, possible cure to cancer. Well, this is not my question. My question is that if they can inhibit and destroy this Lamin A, wouldn't it also be possible to repair it? This would in turn not necessarily prolong life, but maybe make us more physically and mentally capable while we are alive? Anyone else know anything about this?


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  3. #2  
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    It is always more difficult to fix something than destroy something. Many drugs work by inhibiting the action of various enzymes (proteins), but as far as I know there is not one drug on the market that repairs a specific damaged protein.


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  4. #3  
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    Quote Originally Posted by daniel tillett
    It is always more difficult to fix something than destroy something. Many drugs work by inhibiting the action of various enzymes (proteins), but as far as I know there is not one drug on the market that repairs a specific damaged protein.
    He's got a point.
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  5. #4  
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    There are specific inhibitors for enzyms, and the "destruction" of enzyms, which are proteins, takes part in your body all the time and is catalysed by so called protelithic enzyms, in this manner proteins are broken down in the course of digestion.

    There is however nothing which repairs enzyms.
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