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Thread: genetic in anomalies such as aneuploidy

  1. #1 genetic in anomalies such as aneuploidy 
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    What implications does the mitotic spindle have on anomalies such as aneuploidy and on which cell phase is given, mitosis or meiosis?


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    Forum Sophomore M_Gabriela's Avatar
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    The mitotic spindle is a microtubular structure. The microtubules join/link to chromosomes and are responsible of separating them (both homologous chromosomes or sister chromatids) in anaphase (both mitotic and meiotic). In that phase the depolymerization of microtubules from from the centrosome pulls chromosomes to opposite poles...


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    Forum Sophomore M_Gabriela's Avatar
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    If mitotic spindle is not attached correctly.... then the separation fails... then you get gametes with no chromosome or two copies of the same chromosome...
    There should be just one (gametes are haploid)
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  5. #4  
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    Quote Originally Posted by M_Gabriela View Post
    If mitotic spindle is not attached correctly.... then the separation fails... then you get gametes with no chromosome or two copies of the same chromosome...
    There should be just one (gametes are haploid)
    Ah good, I hoped you would show up to deal with this one.
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    according to the literature "Structural chromosomal abnormalities are caused by disruption or incorrect union of chromosomal segments. Several of the structural chromosomal abnormalities result in disease. Structural reorganization is considered balanced if the complete chromosomal set is present, although its distribution is not normal, and is considered unbalanced if there is a lack or a lot of information. Unbalanced rearrangements include deletions, duplications, or insertions of chromosomal segments. If a chromosome undergoes two breaks and the broken ends join together to form a circular chromosome, a ring or annular chromosome is generated."

    what implications would the circular chromosome formation bring?
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