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Thread: What happens to insulin once it has bound to its receptor?

  1. #1 What happens to insulin once it has bound to its receptor? 
    Ann
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    Hi everyone,

    I'm wondering what happens to the insulin peptide once it has bound to its receptor. Is it internalized into the cell or is it targeted for degradation?

    Thank you in advance!


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  3. #2  
    Forum Professor Zwolver's Avatar
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    And here is the solution.



    *It will be degraded after binding to the receptor, as it cannot leave without degrading, and the receptor needs to be free again.


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    Time Lord Paleoichneum's Avatar
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    Hmmm, that actually does not seem to address the opening question, which was about the fate of the Insulin molecules themselves after bonding. Not about the reaction within the cell.

    EDIT: Just saw the note at the bottom of the picture regarding degradation, nevermind
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    Forum Professor Zwirko's Avatar
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    Insulin receptor-insulin complexes are internalised by the cell and fed into to the endocytic membrane pathway. The internalised receptors are either recycled back to the plasma membrane or degraded. Somewhere along this endocytic pathway insulin is released from the receptor and channeled into degradative pathways. In some cases the insulin is shuttled around inside the cell before being released back into the extracellular environment (why, I don't know).

    Insulin that is not bound to receptors is rapidly cleared by the liver and kidney in a matter of minutes.
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