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Thread: Are prion proteins functional in their denatured state?

  1. #1 Are prion proteins functional in their denatured state? 
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    Do the denatured prions (Infectious type) interact with normal prions or is it the other way around?

    By ''functional'' I mean do these denatured but infectious proteins perform any actual chemical reactions.


    Last edited by FrankBaker; July 2nd, 2014 at 03:35 PM.
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  3. #2  
    exchemist
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    Quote Originally Posted by FrankBaker View Post
    Do the denatured prions (Infectious type) interact with normal prions or is it the other way around?

    By ''functional'' I mean do these denatured but infectious proteins perform any actual chemical reactions.
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    Forum Professor Zwolver's Avatar
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    Most probable response would be, yes. A protein always has a function, denatured or not. However, its efficiency depends on the exact shape, and places of certain compounds and connections.

    The sickness a prion causes however does not come from the function of the protein, rather than the lack of the protein it denatures.
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    But how does an infectious prion convert normal prions?
    Supposedly an infectious prion is very rigid
    Enzymes are flexible
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    Moderator Moderator Cogito Ergo Sum's Avatar
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    Quote Originally Posted by Zwolver View Post
    The sickness a prion causes however does not come from the function of the protein, rather than the lack of the protein it denatures.

    Do prions also not have the tendency to aggregate into enormous clusters, thereby interfering with the inner workings of the cell?
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    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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