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Thread: apoezyme equals allosteric regulation?

  1. #1 apoezyme equals allosteric regulation? 
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    Apr 2013

    I'm sort of confused with the concepts apoenzyme and allosteric regulation. I know a apoenzyme needs a cofactor to work this can be a ion or a organic molecule (=coenzyme) or both forming an active enzyme (holoenzyme). My question now is with allosteric regulation more specifically allosteric activation isn't this also a apoenzyme? I'm guessing it's not the same. But where exactly lies the difference?

    Thanks in advance

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  3. #2  
    Moderator Moderator Cogito Ergo Sum's Avatar
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    Jun 2013
    They are, as you state, not the same.

    Cofactors merely act as the "chemical teeth". They aid to catalyze the reaction, but they are not the activators nor inhibitors of the enzyme.
    Allosteric regulation is simply that a substance binds on an enzyme other than at the substrate binding site and alters the enzyme activity.

    If this does not clarify your question, I will look for an enzyme that can illustrate my explanation.

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  4. #3  
    Forum Professor Zwolver's Avatar
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    Well, actually, after wikiing for about 1 min. My conclusion would be its not the same, but it doesn't exclude the other part either. There are so many apo-enzymes, and some allosteric regulation mechanisms can use an inorganic co-factor. But not all of these regulations do. Also, sometimes the enzyme used in allosteric regulation is active already, and it doesn't use this cofactor to become active. The big difference is, there are 2 mechanisms on allosteric regulation (up and downregulation), and only the co-factor bond at apo-enzymes, which could count as 1 mechanism.

    Just to clarify your ideas weren't nonsense.. It made me think over this whole proces..
    Growing up, i marveled at star-trek's science, and ignored the perfect society. Now, i try to ignore their science, and marvel at the society.

    Imagine, being able to create matter out of thin air, and not coming up with using drones for boarding hostile ships. Or using drones to defend your own ship. Heck, using drones to block energy attacks, counterattack or for surveillance. Unless, of course, they are nano-machines in your blood, which is a billion times more complex..
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