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Thread: Lab on a Chip system identifies your DNA

  1. #1 Lab on a Chip system identifies your DNA 
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    Hey, I just came across this idea that sounds really cool in theory, but I'm wondering if anyone out knows if it's actually technically possible:

    Lab-on-a-chip detectors marblar.com/challenge/micro-mixer/idea/1237

    So the analyte is passively mixed by a tiny microfluidic mixer which is then passed onto the chip that detects DNA.This apparently would be a much faster process than the current system.

    However, I have doubts that this is necessary because they are already doing this without the mixing device. What do you guys think?


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    Quote Originally Posted by DanBayley View Post

    So the analyte is passively mixed by a tiny microfluidic mixer which is then passed onto the chip that detects DNA.This apparently would be a much faster process than the current system.

    However, I have doubts that this is necessary because they are already doing this without the mixing device. What do you guys think?

    I have two questions for you:
    1. How do passively mix a volume in the range of nL and pL?
    2. Would mixing result in faster analyses?


    "The only safe rule is to dispute only with those of your acquaintance of whom you know that they possess sufficient intelligence and self-respect not to advance absurdities; to appeal to reason and not to authority, and to listen to reason and yield to it; and, finally, to be willing to accept reason even from an opponent, and to be just enough to bear being proved to be in the wrong."

    ~ Arthur Schopenhauer, The Art of Being Right: 38 Ways to Win an Argument (1831), Stratagem XXXVIII.
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    When I said passive, I meant the device is non-powered and the two liquids will mix by controlling the rate of flow through the device. When the rate of flow is correct there will be enough pressure to cause the diaphragm to vibrate. The vibrations change the flow of the fluid in such a way that the two will mix effectively.


    If DNA is being detected through DNA hybridisation the DNA strands must be well mixed so they can attach to complimentary molecules (molecules, that when attached, will allow the DNA to be detected). The current mixing systems, such as a static mixer, are much slower and DNA strands may not attach to the probe molecule if not mixed well enough.
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