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Thread: What is a sub/supra-stimulatory concentration?

  1. #1 What is a sub/supra-stimulatory concentration? 
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    I've received a data analysis task, which involves interpreting insulin secretion levels in response to varying glucose concentrations (in addition to neurotransmitters and other drugs). One question asks 'Do cholinergic neurotransmitters stimulate insulin secretion? If so, do they initiate secretion (i.e. at a sub-stimulatory concentration of glucose?)'. I know that cholinergic transmitters don't initiate but rather enhance secretion, but for some reason I can't wrap my head around what 'sub-stimulatory' means, in this context or any other for that matter. Anyone who can shed light on this will have my blessings.

    Ray


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  3. #2  
    Forum Ph.D.
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    Sub stimulatory would be a level of the substance being investigated that is less than the threshold necessary to initiate stimulation. It sounds like they are asking if chollinergic neurotransmitters will cause insulin secretion in a glocose solution that is too low to to stimulate insulin secreation without them.


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  4. #3  
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    Ahh i see, thank you!
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