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Thread: Syndecans

  1. #1 Syndecans 
    Forum Freshman TAMB0's Avatar
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    Does anyone know anything about syndecans? Im doing a paper on them and would like someone to bounce things off of.

    Syndecans are a group of cell membrane glycoproteins involved in cellular adhesion and signalling with proposed involvement with cancer.

    I will also post in the chemistry forum.


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  3. #2  
    Life-Size Nanoputian Flick Montana's Avatar
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    I have a very basic knowledge of them from a short time working in RTK research in school. I understand their function and when it comes to cancer I know they have been associated with multiple myeloma. Other than that, I'd have to dig.

    More specifically, what is your paper about? Just to satisfy the curiosity of someone who sometimes wishes he'd gotten involved in medical research...


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  4. #3  
    Forum Freshman TAMB0's Avatar
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    Thanks for the response Flick. My paper will be about designing a year-long research project for using syndecans in relation to cancers. I think ill narrow it down to finding ways to modify the expression of syndecans (quantitatively) as a method of treating cancer. I could also go the harder route of trying to modify syndecans to make them less interactive with cancer cell lectins (binding sites).



    There's a few good papers out there already.

    Beauvais, D.M. and A.C. Rapraeger, Syndecans in tumor cell adhesion and signaling. Reprod Biol Endocrinol, 2004. 2: p. 3.

    David J. CAREY, Syndecans: multifunctional cell-surface co-receptors. Biochem. J. (1997) 327, 116


    Lee, Hawon, et al. Syndecan-2 cytoplasmic domain regulates colon cancer cell migration via interaction with syntenin-1. Biochemical and Biophysical Research Communications, 2011, Vol.409(1), pp.148-153

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  5. #4  
    Life-Size Nanoputian Flick Montana's Avatar
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    Sounds interesting. Keep us updated.
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