Notices
Results 1 to 2 of 2

Thread: What genetics determine size of body?

  1. #1 What genetics determine size of body? 
    The Doctor Quantime's Avatar
    Join Date
    Jun 2007
    Location
    United Kingdom
    Posts
    4,546
    What part of the chromosone decides how the body grows? I am really confused as to how if there is a 99.8% genetic similarity between two persons that they can have vast genetic diversity. What determines if one is short or tall? Wider or thinner boned? How come it can be so diverse and how could genetic engineering change this?

    I am asking for a scientific fact here on genetics and then for that fact to be extrapolated into a theory as to how one would manipulate height in the genome for instance. Can you 'target' height?


    "If you wish to make an apple pie from scratch, you must first invent the universe". - Carl Sagan
    Reply With Quote  
     

  2.  
     

  3. #2  
    Forum Bachelors Degree
    Join Date
    Jul 2008
    Posts
    420
    Hiya,

    Height is polygenic and ~80% of variation in height is due to genetic factors. Genome wide association studies (GWAS) have identified a number of single nucleotide polymorphisms (SNPs) throughout the genome that appear to correlate with height phenotype in a statistically signifcant way. HMGA2, GDF5-UQCC, ZBTB38, HHIP have been associated with height across three independent studies. Biological pathways or processes in which the GWAS-identified genes feature include: meosderm development, skeletal development, mitosis, cancer, Hedgehog signalling and chromatin remodelling.

    This is all explained in Peter M Visscher (2008) Sizing up human height variation. Nature Genetics 40: 489-490

    http://www.nature.com/ng/journal/v40...ng0508-489.pdf

    Let me know if you are unable to access the full text and I will send a PDF to you.

    Best wishes,

    Tridimity


    Reply With Quote  
     

Similar Threads

  1. Brain size, Head size and intelligence
    By Heinsbergrelatz in forum Biology
    Replies: 17
    Last Post: December 13th, 2012, 04:49 PM
  2. Replies: 20
    Last Post: May 21st, 2012, 11:16 AM
  3. Replies: 2
    Last Post: January 12th, 2012, 12:09 PM
  4. Can speed and time determine size
    By JAYSFLUID in forum Physics
    Replies: 3
    Last Post: February 6th, 2011, 10:33 AM
  5. Body size and intelligence
    By skeptic in forum Personal Theories & Alternative Ideas
    Replies: 11
    Last Post: April 19th, 2010, 07:57 AM
Bookmarks
Bookmarks
Posting Permissions
  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •