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Thread: Approach to Cancer

  1. #1 Approach to Cancer 
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    How about we look into adopting a new approach to combat cancer, what I am suggesting is that when someone is born cells are taken from a person and these cells are then used to make a 'controlled cancer' that is much virilant than any other cancer but is programmed to burn itself out very quickly. This could then be stored and used in later life to attack and overwrite any forms of cancer a person may get.

    If it is designed to be controlled it would make it reasonably safe to use and could targeted very specifically to affected areas.


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  3. #2  
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    Quote Originally Posted by Chrisgorlitz View Post
    How about we look into adopting a new approach to combat cancer, what I am suggesting is that when someone is born cells are taken from a person and these cells are then used to make a 'controlled cancer' that is much virilant than any other cancer but is programmed to burn itself out very quickly. This could then be stored and used in later life to attack and overwrite any forms of cancer a person may get.

    If it is designed to be controlled it would make it reasonably safe to use and could targeted very specifically to affected areas.
    Oh boy. Where to begin... 1. How would the 'controlled' cancer be made? I suppose that in theory it would be possible to culture human cells in vitro and introduce mutations in known proto-oncogenes and tumour suppressor genes by site-directed mutagenesis, but cancers involve heterotypic interactions with other cell types and with the extracellular matrix. The utility of a 2D 'controlled' cancer would therefore be dubious. Also - how would the cells be programmed to die or senesce in a controlled way? 2. Assuming the creation of a 'controlled' cancer possible - how could it be used to 'attack' sporadic cancers? Do you mean, in the sense that, the 'controlled' cancer would out-compete the sporadic one for nutrients and growth space etc? I don't think that this would work - the sporadic cancer would metastasise to multiple sites in the body. On the whole, I don't think that it's a very good idea. One of the main problems in cancer biology is that cancers tend to evolve resistance to therapeutic agents - the proposed therapy, even if viable, would probably be evaded by the cancer cells.

    What is lacking in the field of cancer biology is a holistic or unified systems biology approach. Researchers tend to focus on pathways and individual components of signalling pathways that are very obviously up- or down-regulated in cancer. The pharma's then take it upon themselves to design novel therapeutic agents to antagonise or promote single pathways or pathway components. Typically, the dosages of the drugs used is very crude also - a sledgehammer approach. Hence the side-effects on other cells of the body. Resistance also tends to develop as it is relatively 'easy' for a cancer cell to evolve resistance to a drug if the drug is targetting only one signalling pathway component. This approach has had some success, and sometimes a few pathways will be targetted in unison, but what is missing is a unified model of the subtleties and nuances of how the pathways and their components interact. In silico modelling holds the most promise here - the aim is to be able to almost 'reverse engineer' the model i.e. if 70% cell death is desired in a tumour of this genetic and proteomic profile, output the precise stimuli that will give this result.


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    Forum Professor Zwolver's Avatar
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    Ive read an interesting article about a new approach to defeat cancer though.

    ScienceDirect.com - The Lancet Oncology - The role of the coagulation system in tumour angiogenesis

    As during angiogenesis there are new bloodvessles formed. As melanoma's usually form these bloodvessles to get enough blood for growth. This can be stopped, due to a tissue factor specific proces. This could slow the growth rate of some tumours, and thus giving a person more time. Also if tissue factor can be linked to tumor cells, and actually stimulating coagulation you can actually dry out the tumour, by cutting off it's blood supply. But we are still a long way from that.
    Growing up, i marveled at star-trek's science, and ignored the perfect society. Now, i try to ignore their science, and marvel at the society.

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    I guess you can maybe do a spin off of that by using stem cells but first we would have to figure out the controlling factors that make them differentiate or de-differentiate from cancer cells. This would be the cure!..but it wouldn't happen because there's just too much money to be made from cancer patients.
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    Quote Originally Posted by Dkav View Post
    I guess you can maybe do a spin off of that by using stem cells but first we would have to figure out the controlling factors that make them differentiate or de-differentiate from cancer cells. This would be the cure!..but it wouldn't happen because there's just too much money to be made from cancer patients.
    Actually it would save money to cure cancer. It are the infective diseases like TBC and HIV that will cost if a total cure would swoop the globe.
    Growing up, i marveled at star-trek's science, and ignored the perfect society. Now, i try to ignore their science, and marvel at the society.

    Imagine, being able to create matter out of thin air, and not coming up with using drones for boarding hostile ships. Or using drones to defend your own ship. Heck, using drones to block energy attacks, counterattack or for surveillance. Unless, of course, they are nano-machines in your blood, which is a billion times more complex..
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    Quote Originally Posted by Zwolver View Post
    Actually it would save money to cure cancer. It are the infective diseases like TBC and HIV that will cost if a total cure would swoop the globe.
    Fair enough, I believe you.) About your previous comment...If you dry out the tumor, by cutting off its blood supply, where would it go? And how could this be done?..you mean if we could activate coagulation in a tumor?..but then you have an embolus!
    The need for an intelligible world begins with the fearfulness of pre-philosophical, pre-literate societies facing an unpredictable world of change and trying to make sense of it.
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  8. #7  
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    Quote Originally Posted by Dkav View Post
    Fair enough, I believe you.) About your previous comment...If you dry out the tumor, by cutting off its blood supply, where would it go? And how could this be done?..you mean if we could activate coagulation in a tumor?..but then you have an embolus!
    Dead tissue will be disposed off trough normal pathways, it will be slowly digested or pushed out of the body, depending on where the tumor lies.
    Growing up, i marveled at star-trek's science, and ignored the perfect society. Now, i try to ignore their science, and marvel at the society.

    Imagine, being able to create matter out of thin air, and not coming up with using drones for boarding hostile ships. Or using drones to defend your own ship. Heck, using drones to block energy attacks, counterattack or for surveillance. Unless, of course, they are nano-machines in your blood, which is a billion times more complex..
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