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Thread: Motor proteins and vesicles inside cells

  1. #1 Motor proteins and vesicles inside cells 
    New Member SOLARIS_7's Avatar
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    I am fully aware of how motor proteins work in the cell and how they carry vesicles along the cytoskeleton, but I have never gotten an answer to how the motor protein physically attaches itself onto the vesicle? Does it have skeletal projections like a flagellum?

    Also, I am curious over how the amino acid tags on the surface of vesicles actually direct motor proteins to carry the vesicles to certain organelles.

    If anyone knows, please respond. Thanks -


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  3. #2  
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    Hi Solaris,It's been a while since I thought about motor proteins.. I am at a conference at present with internet usage limited to my phone, so it makes giving a comprehensive reply difficult. I will research this once I return.In terms of amino acid sequences that direct proteins to certain compartments, I have alwsys wondered the mechanism and never found a satisfactory answer. I think that perhaps molecular biologists just observe that abrogating given amino acid sequences abolishes the correct trafficking of proteins, although the underlying mechanisms may not have been fully elucidated. I will take a quick look on Friday and let you know.Best wishes,Tri


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    Quote Originally Posted by SOLARIS_7 View Post
    I am fully aware of how motor proteins work in the cell and how they carry vesicles along the cytoskeleton, but I have never gotten an answer to how the motor protein physically attaches itself onto the vesicle? Does it have skeletal projections like a flagellum?

    Also, I am curious over how the amino acid tags on the surface of vesicles actually direct motor proteins to carry the vesicles to certain organelles.

    If anyone knows, please respond. Thanks -
    They do it through specific kinesin-binding or dynein-binding 'receptor' proteins

    ScienceDirect.com - Current Opinion in Cell Biology - Principles of cargo attachment to cytoplasmic motor proteins

    Best wishes,

    Tri~
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