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Thread: Amino Acid Sequence

  1. #1 Amino Acid Sequence 
    New Member
    Join Date
    Jan 2012
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    2
    Hello,

    I am wondering what the amino acid sequence is for the medication Tramadol? Yes I know that tramadol is not a protein. However, I do not know how to figure out what the receptor is that binds tramadol. I have been referenced to such websites as NCBI but honestly, I might as well be trying to read something in French. I am not good at science, and I would just like someone to point me in the right direction on how to figure this amino acid sequence out.
    All help will be appreciated.

    I have included the best info that I have found so far. Perhaps it will help? tramadol hydrochloride
    Ashlee


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  3. #2  
    Forum Bachelors Degree
    Join Date
    Jul 2008
    Posts
    420
    Hi nyx.jord,

    ORIGIN
    1 mdssaaptna snctdalays scspapspgs wvnlshldgn lsdpcgpnrt dlggrdslcp
    61 ptgspsmita itimalysiv cvvglfgnfl vmyvivrytk mktatniyif nlaladalat
    121 stlpfqsvny lmgtwpfgti lckivisidy ynmftsiftl ctmsvdryia vchpvkaldf
    181 rtprnakiin vcnwilssai glpvmfmatt kyrqgsidct ltfshptwyw enllkicvfi
    241 fafimpvlii tvcyglmilr lksvrmlsgs kekdrnlrri trmvlvvvav fivcwtpihi
    301 yviikalvti pettfqtvsw hfcialgytn sclnpvlyaf ldenfkrcfr efciptssni
    361 eqqnstrirq ntrdhpstan tvdrtnhqle nleaetaplp
    //
    It appears that tramadol binds the mu-opioid receptor http://www.springerlink.com/content/...e/fulltext.pdf

    Above is the 400 amino acid sequence for just one of the splice variants of the receptor.

    You can find this by visiting the ncbi website National Center for Biotechnology Information then select 'protein' in the drop-down category box on the top left hand side. Type 'mu opioid receptor' into the search box > search. This will generate ~538 results. To narrow your search by species (in this case I am assuming that you are most interested in the human opioid receptor) click on 'homo sapiens' under 'top organisms' on the right hand side (there are 76 hits for this). Double click on the splice variant of interest (the one above is #10 in the list). This will give you all kinds of information relating to publications on the opioid receptor, if you scroll down to the bottom you will eventually find the amino acid sequence.

    Best wishes,

    Tridimity.


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