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Thread: Ribosome

  1. #1 Ribosome 
    Forum Sophomore Dkav's Avatar
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    Dec 2010
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    In protein synthesis, how does the ribosome know when it has to stop adding amino acids to the growing polypeptide chain?

    i know that it terminates when a release factor releases the chain, but how does it know when a functional polypeptide chain is complete?


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  3. #2  
    Forum Professor Zwirko's Avatar
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    Termination occurs when a stop codon on the RNA being translated (UAA, UAG and UGA) moves into the ribosome's aminoacyl site. The stop codon, which is not recognised by any aminoacyl-tRNAs is instead recognised by a release factor.


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