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Thread: The central dogma of molecular biology

  1. #1 The central dogma of molecular biology 
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    What can you tell me about the central dogma of molecular biology?
    I would appreciate if you indicate me some articles or books about this.Thanks. :-D


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  3. #2  
    Forum Cosmic Wizard i_feel_tiredsleepy's Avatar
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    Any introductory molecular biology text, written after 1970 will do the trick.


    "I almost went to bed
    without remembering
    the four white violets
    I put in the button-hole
    of your green sweater

    and how i kissed you then
    and you kissed me
    shy as though I'd
    never been your lover "
    - Leonard Cohen
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  4. #3  
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    DNA -> RNA -> protein

    Unidirectional - except in the case of Reverse Transcriptase, which catalyses the transcription of RNA into DNA.

    In a nutshell. :P
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  5. #4  
    Forum Professor Zwirko's Avatar
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    Basically the CD says that when the information encoded within a nucleic acid is transferred to protein, that information cannot flow backwards from protein to nucleic acid. That is, the final step in the flow of information from nucleic acid to protein is irreversible. Anything else you may read is probably wrong, specifically the idea of the overall flow of information from DNA to RNA to protein.

    The wikipedia article "Central dogma of molecular biology" is quite good.

    One of Crick's papers on the topic:
    Crick, F. (1970) Central Dogma of Molecular Biology. Nature 227, 561-563.

    It's also worth noting that it's neither "central" nor a "dogma". To muddle things even more there are two versions - one by Crick (the original) and a second by Watson. The Watson version (DNA > RNA > protein) gets refuted every other year and is sometimes known as the "Sequence Hypothesis".
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  6. #5  
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    thanx Zwirko, the paper you recommended was exactly what I was looking for.

    http://www.dnalc.org/resources/3d/13...-advanced.html
    (a 3 D animation that is quite interesting, at least for people like me, who don't know too much biology
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