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Thread: Test question...Please help

  1. #1 Test question...Please help 
    Forum Freshman
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    Does anyone know why for 500 million years there were evolutionary conservation between eukaryotic and prokaryotic RNA polymerase and promotor?

    Can't find the answer anywhere :!:

    I'm thinking maybe it was too important for the survival of the organism so even a single mutation would kill the organism off. But then again......it seems too simple.

    And if you have time, can someone tell me why the 3 eukaryotic RNA polymerases were named the way the were.


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  3. #2  
    Universal Mind John Galt's Avatar
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    There is a suggestion in this research article. I have boldened the relevant passage in the abstract. The full article is available via the link.

    Miller et al The evolutionary conservation of DNA polymerase alpha.
    Nucleic Acids Res. 1988 16(16):
    The evolutionary conservation of DNA polymerase alpha was assessed by immunological and molecular genetic approaches. Four anti-human KB cell DNA polymerase alpha monoclonal antibodies were tested for their ability to recognize a phylogenetically broad array of eukaryotic DNA polymerases. While the single non-neutralizing antibody used in this study recognizes higher mammalian (human, simian, canine, and bovine) polymerases only, three neutralizing antibodies exhibit greater, but variable, extents of cross-reactivity among vertebrate species. The most highly cross-reactive antibody recognizes a unique epitope on a 165-180 kDa catalytic polypeptide in cell lysates from several eukaryotic sources, as distant from man as the amphibians. Genomic Southern hybridization studies with the cDNA of the human DNA polymerase alpha catalytic polypeptide identify the existence of many consensus DNA sequences within the DNA polymerase genes of vertebrate, invertebrate, plant and unicellular organisms. These findings illustrate the differential evolutionary conservation of four unique epitopes on DNA polymerase alpha among vertebrates and the conservation of specific genetic sequences, presumably reflective of critical functional domains, in the DNA polymerase genes from a broad diversity of living forms.

    http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract


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  4. #3  
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    ahhhh....I see. Guess my guess wasn't too far off. Thanks a bunch Ophiolite.
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