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Thread: Cancer and Cell Cycle - Cyclins/cdks/other genes?

  1. #1 Cancer and Cell Cycle - Cyclins/cdks/other genes? 
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    General questions about how cancer affects the cell cycle...

    1) Does cancer actually speed up the individual phases of mitosis (prophase, metaphase, anaphase, telophase) ... ie metaphase occurs 100x sooner following prophase in a cancer cell compared to a normal cell? or does cancer just increase the number of times mitosis as a whole is performed?

    2) Also, it seems that cyclins and cdks play a great role in cancer cells. From my understanding, the cyclin and/or cdk becomes defective and is used too much, causing mitosis to repeat without stop. Is this correct?

    3) If I am correct in (2), is there a specific phase in the cell cycle where these cancer inducing cyclins and cdks are found? Are these cyclins and cdks only found in the interphase? Only in G1? Only in mitosis? Throughout all of interphase and mitosis? Only in G2? etc etc



    Thanks!


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  3. #2  
    Forum Cosmic Wizard spuriousmonkey's Avatar
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    all the proteins you mentioned are normal proteins and not limited to cancer.


    "Kill them all and let God sort them out."

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  4. #3  
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    Quote Originally Posted by spuriousmonkey
    all the proteins you mentioned are normal proteins and not limited to cancer.
    Yes, I understand that, but in cancer cells are these proteins mutated or over produced? Also would you mind answering my other questions in my original post?

    Thanks!
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  5. #4  
    Forum Cosmic Wizard spuriousmonkey's Avatar
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    cancer cells are all different.
    "Kill them all and let God sort them out."

    - Arnaud Amalric

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