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Thread: Total gene expression vs. endogenous gene expression

  1. #1 Total gene expression vs. endogenous gene expression 
    New Member
    Join Date
    Mar 2009
    I am reading an article that I would like to present soon called "Virus-free induction of pluripotency and subsequent excision of reprogramming factors".
    However, there is one figure in this article that I find perplexing. In this figure, the researchers are measuring the expression levels of genes in transfected cell lines. In some cases, however, endogenous expression is higher than total expression. How is this even possible? Shouldn't endogenous + exogenous expression = total expression? How can you have negative exogenous expression? Thanks for the help.

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  3. #2  
    Forum Cosmic Wizard spuriousmonkey's Avatar
    Join Date
    May 2005
    inhibition of endogenous expression?

    "Kill them all and let God sort them out."

    - Arnaud Amalric
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