Notices
Results 1 to 14 of 14

Thread: Curing Cancer

  1. #1 Curing Cancer 
    Forum Ph.D. verzen's Avatar
    Join Date
    Dec 2007
    Posts
    919
    Here is a thought... I havn't done too much research on the subject, but T cells go out of there way and take out any outside abnormalities in the human body. What if we used Gene Therapy to "engineer" a T cell to recognize cancer cells as an enemy infiltration. In essence, forcing the T Cells to destroy the cancer cells before the cancer cells grow into full blown cancer. Any stock in this idea?


    Reply With Quote  
     

  2.  
     

  3. #2  
    Forum Cosmic Wizard i_feel_tiredsleepy's Avatar
    Join Date
    Mar 2008
    Location
    Montreal
    Posts
    2,256
    T cells already target cancer cells, the vast majority of cancer cells are killed by the immune system, the ones that develop into a neoplasm do so because they have mutations in the apoptotic pathway, or they have mutations that allow them to avoid detection, or they simply aren't expressing any abnormal MHC levels.


    Reply With Quote  
     

  4. #3  
    Forum Freshman
    Join Date
    Sep 2008
    Location
    The United States
    Posts
    65
    Engineered T cells could easily lead to more cancer because malignancies form when the process of cell death does not occur properly. An altered immune system would only further confuse an already unbalanced body.
    Reply With Quote  
     

  5. #4  
    Moderator Moderator TheBiologista's Avatar
    Join Date
    Aug 2008
    Posts
    2,569
    Quote Originally Posted by Theresa
    Engineered T cells could easily lead to more cancer because malignancies form when the process of cell death does not occur properly. An altered immune system would only further confuse an already unbalanced body.
    That's a bit of a broad generalisation. We alter our immune systems all the time with vaccination, and the system alters itself in response to new infection. As to increasing malignancies, why would we immortalise our engineered T cells?
    Reply With Quote  
     

  6. #5  
    New Member
    Join Date
    Sep 2008
    Posts
    1
    washington (reuters) - cancer experts who probed every gene in tumors from two of the hardest-to-treat cancers found that cancer is much more complicated than anyone thought -- and say they found why a cure is so unlikely after a tumor has spread.

    but they also discovered a potential new way to treat a common and fatal form of brain cancer, and opened the door to finding cancer before it has spread, when it can still be cured surgically, they reported on thursday in the journal science.

    "cancer is very complex -- more complex than we had believed. it is not going to be easy to develop therapies," said dr. bert vogelstein of johns hopkins university in baltimore and the howard hughes medical institute.

    "if you have 100 patients, you have 100 different diseases."

    the findings suggest that popular new targeted therapies such as novartis's gleevec may not work broadly, because they affect only one mutated gene, while cancer is caused by dozens.

    ----------------------------
    gwen

    guaranteed roi
    Reply With Quote  
     

  7. #6  
    Forum Freshman
    Join Date
    Sep 2008
    Location
    The United States
    Posts
    65
    TheBiologista, I meant that a body would recognize the engineered cells as unnatural, which would further disrupt the normal process of cell death and growth. There is already a major disruption inside a human with cancer.
    Reply With Quote  
     

  8. #7  
    Moderator Moderator TheBiologista's Avatar
    Join Date
    Aug 2008
    Posts
    2,569
    Quote Originally Posted by Theresa
    TheBiologista, I meant that a body would recognize the engineered cells as unatural, which would further disrupt the normal process of cell death and growth. There is already a major disruption inside a human with cancer.
    There is no reason to assume that such a recognition would take place. I assume the poster was talking about modifying the patient's own T cells. Of course, the nature of modification might be the key there, but did you have a specific recognition pathway in mind? Recognition of "unnatural" is not something that the body really does.
    Reply With Quote  
     

  9. #8  
    Forum Freshman
    Join Date
    Sep 2008
    Location
    The United States
    Posts
    65
    No, I was not referring to a particular upset, but didn't need to. My point was that engineered cells used as a cure could have easily had the opposite effect. It's true that we can't be certain of it ahead of time, but important to recognize that it's highly likely to happen. After all, our bodies try to protect us from harm by attacking foreign substances.
    Reply With Quote  
     

  10. #9  
    Moderator Moderator TheBiologista's Avatar
    Join Date
    Aug 2008
    Posts
    2,569
    Quote Originally Posted by Theresa
    No, I was not referring to a particular upset, but didn't need to. My point was that engineered cells used as a cure could have easily had the opposite effect. It's true that we can't be certain of it ahead of time, but important to recognize that it's highly likely to happen. After all, our bodies try to protect us from harm by attacking foreign substances.
    Yes but such engineered cells, from the immune point of view, would not constitute "foreign". That is typically determined by recognition of certain cell surface receptors and given that the engineered cells would be "self" T cells, should not be allorecognised.
    Reply With Quote  
     

  11. #10  
    Forum Ph.D. Raziell's Avatar
    Join Date
    Sep 2008
    Posts
    928
    What if cancer isnt a disease, but a cure made by nature - to remove the REAL disease wich is the human species?
    Reply With Quote  
     

  12. #11  
    Forum Cosmic Wizard i_feel_tiredsleepy's Avatar
    Join Date
    Mar 2008
    Location
    Montreal
    Posts
    2,256
    Quote Originally Posted by Raziell
    What if cancer isnt a disease, but a cure made by nature - to remove the REAL disease wich is the human species?
    That would imply conscious intention in nature, which is absurd. Besides being a load of generic misanthropy.

    Also, cancer affects all animals and even plants.
    Reply With Quote  
     

  13. #12  
    Forum Ph.D. Raziell's Avatar
    Join Date
    Sep 2008
    Posts
    928
    Quote Originally Posted by i_feel_tiredsleepy
    Quote Originally Posted by Raziell
    What if cancer isnt a disease, but a cure made by nature - to remove the REAL disease wich is the human species?
    That would imply conscious intention in nature, which is absurd. Besides being a load of generic misanthropy.

    Also, cancer affects all animals and even plants.
    Never knew it affected plants But yeah, would be absurd. Didnt actually believe it myself but it would have a poetic irony in it if it were so.
    Reply With Quote  
     

  14. #13  
    New Member
    Join Date
    Sep 2008
    Posts
    1
    they didn't clone a person just a one of the persons cells that was able to kill the cancer cells.....2.) they cloned hundreds of thousands of that cell and then injected them back into the patient effectively giving him a massive dosage of cancer fighting cells that kicked the cancers ass like chuck norris kicks the bad guys asses.
    --------------------
    jones
    one time ads
    Reply With Quote  
     

  15. #14  
    Forum Ph.D. verzen's Avatar
    Join Date
    Dec 2007
    Posts
    919
    Quote Originally Posted by Raziell
    Quote Originally Posted by i_feel_tiredsleepy
    Quote Originally Posted by Raziell
    What if cancer isnt a disease, but a cure made by nature - to remove the REAL disease wich is the human species?
    That would imply conscious intention in nature, which is absurd. Besides being a load of generic misanthropy.

    Also, cancer affects all animals and even plants.
    Never knew it affected plants But yeah, would be absurd. Didnt actually believe it myself but it would have a poetic irony in it if it were so.
    really, eh? Some people don't watch that much M Night Shalahan (sp?)
    Reply With Quote  
     

Bookmarks
Bookmarks
Posting Permissions
  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •