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Thread: flanking

  1. #1 flanking 
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    Hi guys,

    Quick question, what does 'flanking' mean, exactly, for example in the following context:

    "Perhaps more interesting than the negative sites are the five sites flanking the kinase domain..."

    Does it simply mean 'within' (e.g. within the kinase domain..)

    Thanks,

    Tridimity :wink:


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  3. #2 Re: flanking 
    Moderator Moderator TheBiologista's Avatar
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    Quote Originally Posted by tridimity
    Hi guys,

    Quick question, what does 'flanking' mean, exactly, for example in the following context:

    "Perhaps more interesting than the negative sites are the five sites flanking the kinase domain..."

    Does it simply mean 'within' (e.g. within the kinase domain..)

    Thanks,

    Tridimity :wink:
    It means "around" or "next to".


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  4. #3  
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    Oh right, thanks.

    So, does it mean immediately next to?

    Does the word 'flanking' have strict meaning?

    E.g. say we have: ---site X - KINASE DOMAIN---

    would site X be flanking the kinase domain?

    or if we have: ---site X---site Y---KINASE DOMAIN---

    would site X no longer be flanking the kinase domain? would it be too far away to be described as next to the kinase domain?

    would site Y instead be described as flanking the kinase domain? would site Y also be flanking site x? and vice versa?

    Sorry, ive said flanking so many times now it almost doesnt sound like a word. Sorry to get all pedantic, the little details just matter to me

    Tridimity
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  5. #4  
    Forum Ph.D. Leszek Luchowski's Avatar
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    Quote Originally Posted by tridimity
    Does the word 'flanking' have strict meaning?
    From the Merriam-Webster online dictionary (www.m-w.com):

    Main Entry: flank
    Function: transitive verb
    Date: 1594
    1 a: to be situated at the side of; especially : to be situated on both sides of <a road flanked with linden trees> b: to place something on each side of
    2: to protect a flank of
    3: to attack or threaten the flank of (as a body of troops)
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  6. #5  
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    Does this help?

    http://www.sci.sdsu.edu/~smaloy/Glossary/F.html

    Flanking sequence or flanking region
    The DNA sequence located on either side of a specific genetic locus.
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  7. #6  
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    Ahh, on either side of. Okay, i can sleep now :P

    Thank-you guys!!

    Tridimity :-D
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