Notices
Results 1 to 9 of 9

Thread: Placebo Effect - Tr-woooly examining wooo

  1. #1 Placebo Effect - Tr-woooly examining wooo 
    Suspended
    Join Date
    Sep 2014
    Posts
    172
    METHODS

    A total of 180 patients with osteoarthritis of the knee were randomly assigned to receive arthroscopic débridement, arthroscopic lavage, or placebo surgery. Patients in the placebo group received skin incisions and underwent a simulated débridement without insertion of the arthroscope. Patients and assessors of outcome were blinded to the treatment-group assignment. Outcomes were assessed at multiple points over a 24-month period with the use of five self-reported scores — three on scales for pain and two on scales for function — and one objective test of walking and stair climbing. A total of 165 patients completed the trial.
    Full Text of Methods...


    RESULTS

    At no point did either of the intervention groups report less pain or better function than the placebo group. For example, mean (±SD) scores on the Knee-Specific Pain Scale (range, 0 to 100, with higher scores indicating more severe pain) were similar in the placebo, lavage, and débridement groups: 48.9±21.9, 54.8±19.8, and 51.7±22.4, respectively, at one year (P=0.14 for the comparison between placebo and lavage; P=0.51 for the comparison between placebo and débridement) and 51.6±23.7, 53.7±23.7, and 51.4±23.2, respectively, at two years (P=0.64 and P=0.96, respectively). Furthermore, the 95 percent confidence intervals for the differences between the placebo group and the intervention groups exclude any clinically meaningful difference.
    Full Text of Results...

    http://www.nejm.org/doi/full/10.1056/NEJMoa013259


    Reply With Quote  
     

  2.  
     

  3. #2  
    Suspended
    Join Date
    Sep 2014
    Posts
    172
    ABSTRACT
    This article reports an analysis of the efficacy data submitted to the U.S. Food
    and Drug Administration for approval of the 6 most widely prescribed
    antidepressants approved between 1987 and 1999. Approximately 80% of the
    response to medication was duplicated in placebo control groups, and the mean
    difference between drug and placebo was approximately 2 points on the 17-item
    (50-point) and 21-item (62-point) Hamilton Depression Scale. Improvement at
    the highest doses of medication was not different from improvement at the
    lowest doses. The proportion of the drug response duplicated by placebo was
    significantly greater with observed cases (OC) data than with last observation
    carried forward (LOCF) data. If drug and placebo effects are additive, the
    pharmacological effects of antidepressants are clinically negligible. If they are
    not additive, alternative experimental designs are needed for the evaluation of
    antidepressants.

    Ressults-
    Proportion of the
    Drug Response That Was Duplicated in Placebo
    Groups for Each Antidepressant

    Fluoxetine .89
    Paroxetine .68
    Sertraline .80
    Venlafaxine .73
    Nefazodone .83
    Citalopram .80



    http://alphachoices.com/repository/a...rsNewDrugs.pdf (university study)


    Reply With Quote  
     

  4. #3  
    Anti-Crank AlexG's Avatar
    Join Date
    Mar 2012
    Posts
    2,810
    And what's the point of these posts?
    Its the way nature is!
    If you dont like it, go somewhere else....
    To another universe, where the rules are simpler
    Philosophically more pleasing, more psychologically easy
    Prof Richard Feynman (1979) .....

    Das ist nicht nur nicht richtig, es ist nicht einmal falsch!"
    Reply With Quote  
     

  5. #4  
    Universal Mind John Galt's Avatar
    Join Date
    Jul 2005
    Posts
    14,169
    Quote Originally Posted by AlexG View Post
    And what's the point of these posts?
    That's on a kneed to know basis.
    Reply With Quote  
     

  6. #5  
    Genius Duck Moderator Dywyddyr's Avatar
    Join Date
    Jan 2013
    Location
    Scunthorpe, UK
    Posts
    10,816
    Quote Originally Posted by John Galt View Post
    That's on a kneed to know basis.
    It's a good job the decision over new new mods hasn't been made yet.
    I'm not sure if I'd knight you or execute you for that one!
    "[Dywyddyr] makes a grumpy bastard like me seem like a happy go lucky scamp" - PhDemon
    Reply With Quote  
     

  7. #6  
    Northern Horse Whisperer Moderator scheherazade's Avatar
    Join Date
    Sep 2012
    Location
    Yukon, Canada
    Posts
    4,066
    From the link provided in the first post...
    Conclusions

    In this controlled trial involving patients with osteoarthritis of the knee, the outcomes after arthroscopic lavage or arthroscopic débridement were no better than those after a placebo procedure.
    Years ago, I was in a car accident that left me with scarred tissue above my knees. Being young and female, I was rather self-conscious about this and asked my physician about knee surgery. She responded with several questions related to my comfort and mobility and upon learning that I was in fact an endurance athlete, her sage advice to me was, "Don't f**k with your knees." I was suitably impressed by her choice of language and decided that skirts of mid-calf length would solve the wardrobe concern.

    Given the results of the controlled trial above, I can only be thankful for her honest assessment and she seems to have been well ahead of her time in her thinking.
    Reply With Quote  
     

  8. #7  
    Suspended
    Join Date
    Sep 2014
    Posts
    172
    Quote Originally Posted by John Galt View Post
    Quote Originally Posted by AlexG View Post
    And what's the point of these posts?
    That's on a kneed to know basis.
    hehe
    some see the songs of wooo as a fibula
    Reply With Quote  
     

  9. #8  
    Suspended
    Join Date
    Sep 2014
    Posts
    172
    Quote Originally Posted by scheherazade View Post
    From the link provided in the first post...
    Conclusions

    In this controlled trial involving patients with osteoarthritis of the knee, the outcomes after arthroscopic lavage or arthroscopic débridement were no better than those after a placebo procedure.
    Years ago, I was in a car accident that left me with scarred tissue above my knees. Being young and female, I was rather self-conscious about this and asked my physician about knee surgery. She responded with several questions related to my comfort and mobility and upon learning that I was in fact an endurance athlete, her sage advice to me was, "Don't f**k with your knees." I was suitably impressed by her choice of language and decided that skirts of mid-calf length would solve the wardrobe concern.

    Given the results of the controlled trial above, I can only be thankful for her honest assessment and she seems to have been well ahead of her time in her thinking.
    It`s good to see some new life here. I can relate very much with what you say and i have seen on both ends. The side that invests great faith in science and medicine and get those great results, and the ones who curse medicine and receive those results. I have been both. I can say for myself that it is wise to bless the things as best you can that are great and deserving, worthy, and destroy the things that are not. Someone came to me once when i was first learning to heal. She had an advanced tumour, like a huge octapus, with fingers running throughout her brain. They were terrified. I assured them that medical field was very advanced nowadays and could easily perform those procedures. I believed it too then. I felt and knew she would be perfectly well. And so it is. You can turn over the face of the earth if you believe you can.
    Last edited by emilito; October 8th, 2014 at 03:14 AM.
    Reply With Quote  
     

  10. #9  
    Suspended
    Join Date
    Sep 2014
    Posts
    172
    “People have powerful psychological resources to deal with challenges, but those resources cannot always be used deliberately,” German psychologist Ulrich Weger and Australian psychologist Stephen Loughnan write in the Quarterly Journal of Experimental Psychology. Just as a dummy pill can help people access their ability to tolerate pain, they report, a false conviction can help test-takers relax and improve their performance.
    Their experiment featured 40 undergraduates, each of whom took a 20-question general-knowledge text. Questions ranged from the numerical value of pi to the artist who created Guernica;participants were given four possible answers and instructed to pick the correct one.
    Before doing so, half the students were told that just before each question was asked, the correct answer was momentarily flashed onto the screen. They were informed that this happened too quickly for them to process the information consciously, but assured that it would register in their brains.
    A “demonstration” showed them the process in slow motion, reinforcing their belief that this was really happening. In fact, the researchers write, “the subliminally presented answers of this experimental phase were random letter strings.”
    No matter: “Participants in the placebo condition who believed they had been exposed to the correct answers subliminally scored higher than participants in the control condition,” Weger and Loughnan write.

    Placebo Effect Produces Higher Test Scores - The Science of Society - Pacific Standard: The Science of Society

    Reply With Quote  
     

Similar Threads

  1. How exactly does the placebo effect work?
    By FrankBaker in forum Pseudoscience
    Replies: 13
    Last Post: July 29th, 2014, 05:32 AM
  2. What if you know about the placebo effect?
    By EugeneT in forum Behavior and Psychology
    Replies: 12
    Last Post: March 13th, 2014, 05:38 AM
  3. Whats wrong with the placebo effect.
    By Headdresser in forum Health & Medicine
    Replies: 2
    Last Post: January 26th, 2014, 11:34 PM
  4. Why Does the Placebo Effect Work/
    By jimmythesaint in forum Health & Medicine
    Replies: 20
    Last Post: January 17th, 2014, 09:36 AM
  5. the placebo effect on animals?
    By the man of science in forum Personal Theories & Alternative Ideas
    Replies: 8
    Last Post: March 13th, 2009, 05:51 PM
Bookmarks
Bookmarks
Posting Permissions
  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •