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| biotoy |
 Posted: Fri Apr 25, 2008 8:01 am Post subject: anti-aging |
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Forum Freshman
Joined: 25 Apr 2008
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[quote]An education isn't how much you have committed to memory, or even how much you know. It's being able to differentiate between what you know and what you don't.
Anatole France |
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| KALSTER |
| Posted: Fri Apr 25, 2008 8:08 am Post subject: |
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Forum Professor
Joined: 08 Sep 2007
Posts: 1490
Location: South Africa
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I suspect newbie error... 
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"Gullibility kills" - Carl Sagan |
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| Robbie |
| Posted: Fri Apr 25, 2008 8:10 am Post subject: |
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Forum Bachelors Degree
Joined: 08 Aug 2006
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Location: Dublin
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oh no. 
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There is not enough love & kindness in the world to permit us give it away to imaginary beings.
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| biotoy |
| Posted: Fri Apr 25, 2008 8:15 am Post subject: |
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| u know..enzymes play role in aging..it has been proved in plants.. |
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| biotoy |
| Posted: Fri Apr 25, 2008 8:22 am Post subject: |
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| we all know abt telomerase...which is an enzyme that plays role during cell division....keeps cells young...but one condition is there...what is it..let me know guys... |
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| KALSTER |
| Posted: Fri Apr 25, 2008 8:38 am Post subject: |
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Forum Professor
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Location: South Africa
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....or not.
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"Gullibility kills" - Carl Sagan |
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| Ophiolite |
| Posted: Fri Apr 25, 2008 8:50 am Post subject: |
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Forum Radioactive Isotope
Joined: 25 Jul 2005
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| biotoy wrote: |
| we all know abt telomerase... |
I don't. Why don't you tell me?
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The Universe is not only weirder than we imagine it is weirder than we can imagine. J.B.S.Haldane. |
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| biotoy |
| Posted: Fri Apr 25, 2008 10:55 am Post subject: |
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some trees live for more than hundred years...how is it possible...how this happens...some scientists says that it is because of this enzyme...telomerase...and they say that...when this enzyme maintained in constant level...cells are not aging...is this possible for humans...and what is the mechanisms behind this..  |
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| i_feel_tiredsleepy |
| Posted: Fri Apr 25, 2008 12:35 pm Post subject: |
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Forum Senior
Joined: 21 Mar 2008
Posts: 376
Location: Montreal
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Unfortunately when telomerase is misexpressed in humans it usually leads to cancer.
@Obviously
Telomerase is an enzyme that extends the telomeres which are lengths of unexpressed DNA at the ends of chromosomes. When chromosomes are replicated a bit of the telomere is knocked off everytime. A prominent theory in what causes senescense is that cells will stop replicating once the telomeres get too short.
This isn't the whole picture of what causes aging though. After all your brain cells aren't replicating yet they are still aging. More significant is probably general damage to the mitochondrial DNA from superoxide free radicals, and other damage to the genome that accumulates with time.
They were able to extend the life of mice by 40% too by restricting caloric intake to the bare minimum needed for survival. |
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| Pong |
| Posted: Fri Apr 25, 2008 12:36 pm Post subject: |
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Forum Senior
Joined: 08 Apr 2008
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Yes Biotoy trees have these long clocks in proportion to their generations. Telomerase is a clock, the clock, it appears. So we've found the human aging clock, and may set it at will. We even know how to make it self-winding - immortality and no batteries required.
It's ugly though, because if used for immortality the body essentially becomes one enormous benign tumor. Not good. Would you eat cow brains if starving for protein?
Our first practical application (I hope) will be to accelerate replication losses, in existing cancer cells. Not the other way around. |
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| biotoy |
| Posted: Fri Apr 25, 2008 3:13 pm Post subject: |
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| biotoy |
| Posted: Fri Apr 25, 2008 3:15 pm Post subject: |
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| according to this site telomerase can be helpful for continuous cell division...but it would not lead to cancer...but we have to consider other factors like oxidative stress, glycation and telomere shortening..etc..which involved in aging |
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| Robbie |
| Posted: Fri Apr 25, 2008 4:38 pm Post subject: |
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Forum Bachelors Degree
Joined: 08 Aug 2006
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Location: Dublin
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That is of almost no relevance in the lab for any kind of intervention though.
It is more likely to be dangerous/carcinogenic whatever you're thinking of. And what are you thinking of? If you want to activate telomerase then your thinking of dividing cells for what? Growing? Pathology has quite little to do with this except in cancer.
Telomerase prevents telomere shortening like you said as an other factor.
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There is not enough love & kindness in the world to permit us give it away to imaginary beings.
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| biotoy |
| Posted: Thu May 01, 2008 8:37 am Post subject: |
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